FPIES (Food Protein Induced Enterocolitis Syndrome)

Posted 1.27.11 | Sarah O'Brien

FPIES, or food protein induced enterocolitis syndrome, is a condition that I’ve been hearing about more and more lately. It is not particularly well-known, so I thought we could cover some of the basics in today’s blog.

What is FPIES?

FPIES is a disease that typically affects infants and young children. While it can mimic food allergies, the difference with FPIES is that it is a non-IgE mediated immune reaction in the gastrointestinal (GI) system to one or more specific foods. This means that the IgE antibodies associated with other food allergies are not involved in an FPIES reaction.

Cow’s milk and soy are the most common FPIES triggers, but ANY foods can cause an FPIES reaction (even ones that aren’t typically considered to be allergens like rice and oats).

Common Symptoms of FPIES

Most FPIES reactions happen when a child is very young – just a few weeks or months old. Often it happens when the first formulas or solid foods are introduced (breastmilk doesn’t usually cause an FPIES reaction, even if the mother has eaten a trigger food).

Each child is different, but the most common symptoms of FPIES involve the GI tract and can include projectile vomiting and diarrhea, which means that it is often mistaken for a stomach bug. There is almost always a delayed onset of symptoms - often vomiting occurs 2 hours after eating a trigger food, with diarrhea following 5 hours after eating. Some children experience relatively mild symptoms, while others have such severe vomiting and diarrhea that they can become seriously dehydrated and go into shock.

Diagnosing and Treating FPIES

It can be difficult to diagnose FPIES because blood allergy tests only look for IgE-mediated responses. Usually a diagnosis occurs after repeated reactions. Keeping a food journal may be helpful in identifying triggers if you think your child has FPIES.

Treating FPIES varies depending on the child, their triggers and reactions. For infants with FPIES an elemental formula like Neocate is often used. For some children who have fewer triggers treatment is simply to avoid those foods. Introducing new foods slowly – one at a time and for up to three weeks – is extremely important to identify both safe and trigger foods. If your child has an FPIES reaction, it is important that they remain hydrated to avoid going into shock.

Outgrowing FPIES

Many children with FPIES outgrow the disease by age three, but this can vary based on how severe their symptoms are and which foods they react to. According to an article from Kids With Food Allergies, one study showed that 100% of children with FPIES reactions to barley had outgrown and were tolerating barley by age three, while only 40% of those with FPIES to rice, and 60% to dairy tolerated it by the same age.

To determine if your child has outgrown FPIES it is important to work with your doctor and evaluate it on a food-by-food basis. Atopy patch testing can help assess if your child is ready for an oral challenge in your doctor’s office or hospital (do not attempt without a doctor’s supervision!).

We hope this helps shed some light on an often confusing disease. If any of you have children with FPIES and can share your experiences, please leave a comment!

- Sarah

Read Comments (1)

  • 2012-01-19 | Renee O'Donnell

    This was a great support forum for me and it really helped to get so many ideas from other families dealing with this condition.  My son Bronsen has recently outgrown FPIES and although tentative to try new foods, is officially able to eat whatever he likes!  Our journey to this point, as I’m sure you can relate, was difficult due to the lack of information and resources about FPIES available to us.  Many moms that I met along the way, felt the same, and together we formed the International Association for Food Protein Enterocoltis (IAFFPE).  If you are looking for more information about FPIES, please visit http://www.iaffpe.org on the web and connect with us on Facebook as well https://www.facebook.com/IAFFPE!”

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