Corn Allergy 101

Posted 4.9.15 | Nutrition Specialist

As a Nutrition Specialist here at Nutricia North America, I spend a lot of time talking to patients, parents, and healthcare professionals. Some of the questions I receive most often are “Do Neocate products contain any ingredients derived from corn?” and “Are Neocate products safe for an individual with a corn allergy?” I want to explain a bit more about corn allergy, and then discuss the corn ingredients used in Neocate products.

Corn Protein Allergy

While good data is hard to come by, true allergic reactions to corn are rare, and often difficult to diagnose using standard skin or blood tests. True corn allergies are usually the result of the body being unable to tolerate the protein in corn, so you could call them a corn protein allergy.

Unlike an allergy to protein, some individuals report being sensitive to the carbohydrate in corn, which is even more difficult to diagnose, and not well understood.

Because a true corn protein allergy can be difficult to diagnose through traditional methods, if your allergist suspects a corn allergy, he/she may recommend a food elimination diet in which you avoid corn and any derivatives of corn for a specific period of time (normally two to four weeks). During this time, symptoms will be monitored, specifically to determine if there is an improvement in symptoms while corn is eliminated from the diet.

The next step might be to reintroduce corn foods to your diet to see if symptoms reoccur - this is termed an "oral food challenge," and if you've had severe allergic reactions to food in the past, the allergist may want you to do it in her/his office (called a "supervised trial"). Adding corn foods back into your diet may seem excessive if your symptoms improved on a corn elimination diet, but it's the best, most reliable way to confirm that the corn was the true culprit. If a corn allergy is identified by the allergist, managing the allergy would involve completely avoiding corn and many ingredients derived from corn.

Avoiding Corn

Corn is not among the top eight food allergens in the United States, for which special label information is required by the Food Allergen Labeling and Consumer Protection Act (FALCPA) of 2004. Because corn is not required to be called out on a food label, it is important for individuals with a diagnosed corn allergy to ask their allergist specifically what ingredients they should avoid. Some ingredients, which are more refined and contain trace or undetectable amounts of corn protein, may be acceptable for some patients with a corn protein allergy.

Again, ask your allergist for guidance on what corn ingredients to avoid, but here are some common ingredients in foods that are or can be derived from corn:

  • Corn starch
  • Corn syrup
  • Maltodextrin
  • Vegetable oil
  • Cellulose
  • Caramel

Please note, these are just a few examples and not a comprehensive list of ingredients derived from corn. If you are ever unsure as to whether an ingredient is derived from corn or if you should avoid it, it is best to contact the manufacturer to ask if the ingredient is derived from corn.

Neocate Corn FAQs

Now that we've covered a basic understanding of a corn protien allergy, let’s address these frequently asked questions mentioned earlier. The primary carbohydrate source in each of our Neocate products is derived from corn:

  • The primary carbohydrate source in powdered Neocate products is corn syrup solids
  • The primary carbohydrate source in liquid Neocate products is maltodextrin (from corn)
  • Both corn syrup solids and maltodextrin are derived from corn starch
  • Maltodextrin is structurally similar to corn syrup solids, with slight differences in the degree of refinement
  • An individual who is intolerant to corn carbohydrates would probably not tolerate either maltodextrin or corn syrup solids better than the other
  • Some of the carbohydrate in liquid Neocate products comes from sucrose (table sugar) that comes from beets, so there is less overall corn-derived carbohydrate in these products compared to Neocate powdered products, calorie-for-calorie

Carbohydrates are essential for life, so carbohydrate ingredients are used in almost every nutritional formula.

  • Formulas that do not contain any carbohydrate are used for rare disorders where extremely specialized diets are needed.
  • Corn-derived carbohydrates are used in nutritional formulas as a carbohydrate source because they offer a blend of both simple and complex carbohydrates.
  • Simple carbohydrates are absorbed rapidly, whereas complex carbohydrates are digested and absorbed more gradually.
  • In Neocate products, the carbohydrates are in balance with amino acids (the protein source) and fat to provide a balanced nutritional profile.
  • No Neocate products are completely free of corn-derived ingredients.

That being said, the carbohydrates used in all Neocate products undergo extensive refinement in a multi-step process that includes purification, distillation and drying. This process is designed to remove impurities, including protein and fat that are naturally present in corn. As proteins are what the body responds to in a typical allergic reaction, this removes the trigger for patients with a corn protein allergy. With that said, we cannot make the claim that our Neocate products are completely “corn protein free.” In order to make such a claim, we would need to regularly test for the presence of corn protein, which we do not do. (At this time, there is no validated lab test for corn protein.)

We cannot say with certainty that Neocate is “safe” for you or your child – that’s a question for your healthcare team. It is important to note that leaders in food allergy diagnosis and management have indicated that true corn protein allergy has been considered rare, but that evidence is limited. Hopefully there will be better data about how common true corn protein allergy is in the near future.

Experts have reported that a majority of patients with corn protein allergies tolerate refined corn syrup solids with no allergy symptoms. In practice, these healthcare teams do not counsel patients who are allergic to corn to restrict corn syrup solids from their diet. However, no two patients are the same. If you have questions about the safety of the corn syrup solids or maltodextrin in Neocate, it would be best to discuss this with your healthcare team, especially a board-certified allergist, to see if they recommend a supervised trial of a corn elimination diet or other testing to see if Neocate is appropriate.

Since we’re on the topic of corn, I figured I would mention two facts that are of importance to many Neocate families. The corn from which Neocate's carbohydrate ingredients are sourced is certified by the suppliers not to be genetically modified. In addition, the corn syrup solids used in Neocate products would not be expected to contain fructose and are not the same as “high fructose corn syrup” or “HFCS”. HFCS is produced from corn starch in which about half of the glucose molecules have been chemically converted to fructose. Many consumers prefer to avoid HFCS for a number of reasons, and we do not use this ingredient in Neocate products.

-Kendra Valle, RDN


Image source: Liz West


Read Comments (6)

  • 2016-03-12 | Lori

    Do you test for glyphosate as it has been found in other neonate formulas in the U.S.?  Also, how is the corn certified and who specifically certifies it?  Is it certified by actual test or by affidavit?  Thank you.

  • 2016-03-12 | Kathy Brady

    Corn allergy is NOT rare. It is, however, hard to diagnose because corn has multiple proteins in it—all of which are not included in allergy testing. There is not a need to use corn. It would be nice if one company would step forward and be a leader in completely corn-free formula. As it is, there are infants and their parents left stranded to try to make their own formula at home. Not ideal from a nutritional standpoint.

  • 2016-03-21 | Neocate Admin

    @Lori: Thank you for your response, Lori. We would need to obtain further details regarding your inquiry in order to most accurately answer your questions. For further assistance, please feel free to contact our team of Nutrition Specialists at 1-800-365-7354, option 2 or at .(JavaScript must be enabled to view this email address).

    @Kathy Brady: Thank you for your feedback; we certainly understand your concerns. We’ll keep an eye out for updated prevalence data on corn allergy (currently limited), and we’ll pass your comments along to our Product Development team.

  • 2016-11-21 | Erin Daugherty

    To Kathy Brady: Neocate does make a powder of just Amino Acids… Our dietician worked with us to use that formula, add beet sugar and a variety of oils (not corn!) to make a complete formula that is amino acid and corn free.It can be done

  • 2017-05-22 | Linda F. Palmer

    There is a reason why corn allergy is considered so “rare.” It is because an extremely narrow definition is purposefully applied to the term. Archer Daniels Midland makes sure that other reactions are not recognized. Just as your words above imply (I know you need to protect your product’s reputation), the usual message is basically “don’t worry if corn syrup and other corn products make you or your baby sick, because it’s not an allergy. Well, personally, I prefer to avoid anything that makes me feel bad, and when my baby reacts to a food with diarrhea and vomiting, I tend to think it’s not providing him with the best nutrition.

    When my child was an extremely corn-sensitive baby, I spent time regularly on an online “Avoiding Corn Forum;” a large group of corn allergic and sensitive people and parents trying to find our way to avoiding uncomfortable, sickening, and health-challenging reactions. 20 years ago, we heard about a large corn allergy study looking for volunteers. About 60 of us volunteered (ourselves or our children). They took only one, because they did not want anyone who had any kinds of reactions besides hives or breathing problems. Their study conclusion was that corn allergy was very rare. Isn’t that interesting how “science” works. Too bad it’s not actually helpful for food-sensitive infants who have no access to human milk from a woman who is avoiding foods that the child reacts to.

  • 2017-05-25 | Nutrition Specialist

    Dr. Palmer,
        I can assure you we don’t tell parent’s “don’t worry” - we’re not the experts, and we don’t have all the answers! We always refer consumers back to healthcare providers, such as yourself, for their guidance and to discuss this topic further.
        We know that there’s a lot of interest among consumers and healthcare professionals in both corn allergies and less-well-defined corn sensitivities. We try to provide balanced, factual information based on the available evidence and the practice of board-certified allergists. We’re not familiar with any efforts of Archer Daniels Midland, or the research you referenced, so we can’t comment on that. We promise we’ll do our best to keep up with available evidence to keep this post updated.
        If you ever have news on clinical trials that are actively recruiting to study corn allergy - particularly trials supported by government grants - please let us know, we’d be happy to share that with our readers!
    Rob McCandlish, RDN

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Food Allergy Living is a resource for parents of children with food allergies, brought to you by Nutricia, the makers of Neocate. For more in-depth information about our purpose & authors, see our About Food Allergy Living page.