Your Most Common Neocate Questions Answered

Whether you are new to Neocate, or your child has been on it for a few years, it is natural to have questions about the formula, and how it works. That’s why we’ve compiled a list of frequently asked questions we have been receiving lately, and are using this blog post to answer them. We hope that after reading this post, your questions will be answered!

Here are some answers to our most frequently asked questions:

What makes Neocate different from the formulas at the grocery store?

Neocate is a specialized elemental nutrition product. The formulas you find at the grocery contain whole proteins or protein fragments (hydrolysates), which are derived from cow milk or soy. These formulas have more potential to cause an allergic response than nutrition products made from free amino acids.

100% amino acid-based formula NeocateProtein in formulas containing whole or partial milk proteins


How long will an open can of Neocate last?  When does it expire? Is it good past the expiration date?

Neocate is good for 30 days after you open the can.  You can find the expiration date on the bottom of each can. We do not recommend using any Neocate product after the expiration date.

How long can Neocate be kept once it has been prepared?

Neocate can be kept at room temperature for four hours. If your baby has fed from the bottle, you should discard any remaining formula within an hour to prevent spoiling. Prepared Neocate can be kept in the refrigerator for 24 hours. Visit Neocate’s mixing instructions for more information.

How long can Neocate hang for tube feeding after being mixed?

Four hours maximum. Discard any remaining formula after four hours and prepare a new batch.  

The instructions on the can say to use sterile water. I don’t know what sterile water is. How can I get it? Can I use bottled water?

To make sterile water, bring water to a rolling boil for two minutes and allow it to cool for 20 to 30 minutes. You can store sterile water in sterile glassware with a clean lid. Sterile water should be used within 24 hours. Many parents find it easiest to boil water in the morning to last for the whole day. Most bottled water is not sterile, unless the label specifically states “sterile” on the label. Please check with your healthcare provider if you have questions about the need to use sterile water to prepare Neocate Infant DHA/ARA.

When will I see an improvement in my child after starting Neocate?

Some children show improvement quickly while others may take a little longer. Severe food allergies can cause inflammation and irritation. As with a cut or burn, this takes time to heal.

Controlled clinical studies with a food elimination diet and Neocate showed improvement in diarrhea, blood in stool and vomiting in as little as three days in infants and children with diagnosed cow milk allergy. Improvement in gastroesophageal reflux and skin irritations, such as eczema and atopic dermatitis, were reported in 14 days.

For children on an elimination diet, it’s important to stick to your doctor or dietitian’s instructions.

  • If you’re trying a maternal elimination diet and still breast-feeding, eat only the foods your doctor or dietitian suggests. 
  • If you’re trying an elimination diet with your child using Neocate, do not introduce any other formula or foods until directed by your doctor or dietitian. 

My baby’s bowel movements have changed since starting Neocate. Is this normal?

Yes, this is perfectly normal and common. Stools can change in consistency and color when a child is introduced to an hypoallergenic formula like Neocate. The reason for green is that Neocate is a very simple form of nutrition. It’s a natural effect of taking a formula like Neocate and does not affect your baby’s health—that’s why our motto is “Green Is Glorious.”

Note: Green stools are less common on formulas with prebiotic fiber, like Neocate Syneo Infant or Neocate Junior. You can read more about changes in stool with formulas like Neocate here. What other questions can we answer for you?

Published: 01/21/2016
Carolyn Ricciardi
Hello Aliyan, Our products are medical foods, intended for use under medical supervision. For this reason, we always refer our patients to their health care providers for guidance in selection of an appropriate formula. To answer your second question - most children grow out of their food allergies by age 5 but for some, allergies persist into adulthood. Our formulas do not treat allergies, rather they help to manage allergies and related conditions. Please also note that you have reached Nutricia North America (United States and Canada). Nutricia has offices around the globe and each Nutricia location carries a different portfolio of products. For the most accurate answers to your product questions, it is best to contact Nutricia in your country.
Hi, My baby is 5 and half months old, he has a cow milk allergy since he was 2 months, I have two questions. 1. We have been giving Neocate Infant LCP formula since he was 2 - 3 months of age but apparently we got to know the distributors are out of stock from it. However, they have Neocate Junior (Unflavored) in stock. The pediatrician/Gastroenteritis asked us to give him Neocate Junior. I was wondering is it okay to give the Junior formula to our 5 and half months old baby. 2. For how long the cow milk allergy lasts in infants and does the formula treat the allergy?
Rob McCandlish
Hi Linda! Recent updates to Neocate Junior included the addition of prebiotic fiber to all flavors.*

Added fiber in hypoallergenic formulas can mean stools have more "typical" color & consistency than formulas without fiber. Read more about prebiotics and stools here!

We've never noticed stains like you describe. Some families clean or soak bottles right after formula is done. Other 'natural' cleaning agents or even a soak in hydrogen peroxide solution might help.

Let us know if you find any tricks!

*Neocate Junior is available Unflavored either with or without prebiotic fiber

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