Your Most Common Neocate Questions Answered

Whether you are new to Neocate, or your child has been on it for a few years, it is natural to have questions about the formula, and how it works. That’s why we’ve compiled a list of frequently asked questions we have been receiving lately, and are using this blog post to answer them. We hope that after reading this post, your questions will be answered!

Here are some answers to our most frequently asked questions:

What makes Neocate different from the formulas at the grocery store?

Neocate is a specialized elemental nutrition product. The formulas you find at the grocery contain whole proteins or protein fragments (hydrolysates), which are derived from cow milk or soy. These formulas have more potential to cause an allergic response than nutrition products made from free amino acids.

100% amino acid-based formula NeocateProtein in formulas containing whole or partial milk proteins


How long will an open can of Neocate last?  When does it expire? Is it good past the expiration date?

Neocate is good for 30 days after you open the can.  You can find the expiration date on the bottom of each can. We do not recommend using any Neocate product after the expiration date.

How long can Neocate be kept once it has been prepared?

Neocate can be kept at room temperature for four hours. If your baby has fed from the bottle, you should discard any remaining formula within an hour to prevent spoiling. Prepared Neocate can be kept in the refrigerator for 24 hours. Visit Neocate’s mixing instructions for more information.

How long can Neocate hang for tube feeding after being mixed?

Four hours maximum. Discard any remaining formula after four hours and prepare a new batch.  

The instructions on the can say to use sterile water. I don’t know what sterile water is. How can I get it? Can I use bottled water?

To make sterile water, bring water to a rolling boil for two minutes and allow it to cool for 20 to 30 minutes. You can store sterile water in sterile glassware with a clean lid. Sterile water should be used within 24 hours. Many parents find it easiest to boil water in the morning to last for the whole day. Most bottled water is not sterile, unless the label specifically states “sterile” on the label. Please check with your healthcare provider if you have questions about the need to use sterile water to prepare Neocate Infant DHA/ARA.

When will I see an improvement in my child after starting Neocate?

Some children show improvement quickly while others may take a little longer. Severe food allergies can cause inflammation and irritation. As with a cut or burn, this takes time to heal.

Controlled clinical studies with a food elimination diet and Neocate showed improvement in diarrhea, blood in stool and vomiting in as little as three days in infants and children with diagnosed cow milk allergy. Improvement in gastroesophageal reflux and skin irritations, such as eczema and atopic dermatitis, were reported in 14 days.

For children on an elimination diet, it’s important to stick to your doctor or dietitian’s instructions.

  • If you’re trying a maternal elimination diet and still breast-feeding, eat only the foods your doctor or dietitian suggests. 
  • If you’re trying an elimination diet with your child using Neocate, do not introduce any other formula or foods until directed by your doctor or dietitian. 

My baby’s bowel movements have changed since starting Neocate. Is this normal?

Yes, this is perfectly normal and common. Stools can change in consistency and color when a child is introduced to an hypoallergenic formula like Neocate. The reason for green is that Neocate is a very simple form of nutrition. It’s a natural effect of taking a formula like Neocate and does not affect your baby’s health—that’s why our motto is “Green Is Glorious.”

Note: Green stools are less common on formulas with prebiotic fiber, like Neocate Syneo Infant or Neocate Junior. You can read more about changes in stool with formulas like Neocate here. What other questions can we answer for you?

Published: 01/21/2016
Alexa Klein
Dear Becca, Thank you for reaching out with your inquiry. As long as the water has been sterilized, it's okay if it is a mixture of the recently boiled water and previously boiled water that has cooled. We just don't want the water to be too hot when mixing with the formula. For Neocate LCP, the water should be no hotter than 50°C (122°F). We recommend the bottle be discarded 1 hour from the start of the feed. Repeated reheating can affect the quality of the formula, so we do recommend that you avoid reheating the same bottle multiple times. If you need to gently warm the bottle than you could try placing the bottle in a container of warm water. I hope this helps clarify some of your questions. Have a nice day!
Hi i recently started using neocate lcp to try and help eczema symptoms. I am wondering though as i can see it says not to mix the formula with boioed water that hasnt cooled for at least 20-30 min. Can i keep sterile cool water and then mix that with freshly boiled water to get the correct temperature for the baby to drink at and then add the formula into that. So the actual water wont be hot but it will have had added to it hot freshly boiled water but cooled straight away down by the cooler sterile water. Also i am finding that the baby sometimes wont finish the bottle if she stops to be winded etc, by the time she is ready for a bit more the bottle has cooled too much that she wont take it at that temperature. My understanding is that it should be discarded but then it means having to make more each time this happens. As a resuly a lot of formula is being wasted. Can the half eaten bottle not be re warmed again during the feed if necessary?
Alexa Klein
Hi Jordan, It's possible that your baby has noticed a taste difference between Neocate and Aptamil Pepti 1 and may need some time to adjust. This is similar to the unfamiliar taste of a new vegetable once an infant reaches solids, which research shows can take up to 15-20 times before they get used to the taste and accept it – it often takes a few days for them to adjust to Neocate. The best advice we can give you is to ask your healthcare team for any advice they have first. The second best advice is to download our helpful guide - "A Guide to Transitioning to Neocate" - available on that is full of great tips - Neocate Transition Guide
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