What to expect when starting Neocate

We talk to familes who use Neocate all the time, usually when they call us with questions. The most common questions we get come from families who are new to Neocate and starting to use Neocate Syneo Infant or Neocate Infant, the infant formulas of the Neocate family. Remember: Your healthcare team is familiar with your little one’s medical care, so their advice and guidance is more important than what we have to say!

We want to make sure you know what to expect when starting Neocate. If you’re one of these families, read on for answers to some of these questions. Many of these questions come up during the first week you’ll be using Neocate. We’ll walk you through some of the most common questions we get, and our best answers to those questions. We can almost guarantee you will be glad you did, even if you didn’t think you’d have any questions at all!

How long does it take to see results with Neocate?

That is one tough question to answer! The best we can tell you is that, generally, consensus guidelines and healthcare teams who work with infants suspected to have food allergies suggest staying on a new hypoallergenic formula for about 2 weeks. This allows time for your little one to adjust to the new formula. As you probably know by now, starting any new formula comes with a bit of a transition period.

Every baby is different, keep that in mind when reading this list. Some parents have told us that they’ve noticed changes as soon as the first few days, but change can take time. Some research shows it can take that full 2 weeks to see the full improvement in symptoms of food allergy. Be sure to talk to your baby’s healthcare team if you are unsure about any changes you see.

Will I see any changes in my baby’s diapers?

We’re not used to predicting the future, but the best answer to this question is “Yes, probably.” If this website would let us add an emoji here, we would! It’s hard to say for certain what anyone will experience, because every baby is different. (That’s not a cop out, we swear, it’s true!) We can tell you what we hear from a lot of parents, though.

A lot of parents tell us that they see a change in the color of bowel movements after they switch to Neocate. The color a lot of parents tell us they see is green. Yes, you read that right: Green! It can range from a very dark green (think hunter green) to a “true” green (think forest or hunter green).

Don’t be alarmed, though. This is common for most hypoallergenic formulas, because of how it’s digested and absorbed. (The exception is formulas with prebiotic fiber, like Neocate Syneo Infant or Neocate Junior.) If you really want to know more about what causes this color, we suggest talking to a microbiologist and a gastroenterologist! Or read more here.

How long will the diapers be this color?

Another great question! The color can change from day to day, like it does for everyone. Some families tell us that they saw variations of this color as long as their infant was using Neocate. For other families though, the color has changed after a few days or weeks to a more yellow-ish/khaki/tan color. So the color may change, or it may stay pretty stable. Again, more here.

How many diapers will I have to change per day? And what about stool consistency?

Nobody likes changing diapers. Truly. One thing to know when starting Neocate is that the frequency of the stools per day may decrease. That’s not a rule – remember: every baby’s different. But most parents tell us that on Neocate they were eventually only changing diapers for a bowel movement once every day or two. That’s because Neocate has amino acids as the source of protein and ingredients that are very broken down and low residue. This means that for a baby who drinks Neocate, there is usually less poop coming out the other end.

With Neocate, you can probably expect a change in stool consistency. For some infants stool may become more loose, and for others it may become more formed. A lot of parents tell us the stool with Neocate becomes pasty, so not too loose, but also not too formed (remember, you wanted us to be honest!). With Neocate Syneo Infant, stools may be softer, more like breastfed infants, than with other hypoallergenic formulas that don’t contain fiber.

You may see the consistency change in the first days and weeks after starting Neocate before you find out what’s “normal” for your little one. Again, though, check with your little one’s healthcare team for their guidance. If your little one hasn’t had a bowel movement in a while and/or seems uncomfortable, speak with her doctor.

What about other side effects of digestion, like gas?

With any change in formula, there may be some changes in your baby’s gas (or flatulence). Changes are especially common in the first few days/weeks. Amino acid-based formulas like Neocate are no exception, especially because they’re digested and absorbed differently to other formulas.

A lot of parents tell us that they notice more gas in the first days/weeks with Neocate, or a change in the smell of gas. (You wanted our honest answers, right?) More gas may cause some temporary discomfort or fussiness. After about 2 weeks, the gas should return to what is typical for your baby, or your baby may just adjust.

While we’re on the topic of digestion and diapers, there are a few other factors to be aware of that can influence changes. The introduction of solid foods into the diet can cause some change in color, consistency, and frequency of stools, as well as gas. Also medications (like antibiotics) can cause changes.

Neocate seems to have a thin, watery consistency. Is that normal?

You may have noticed that Neocate formulas seem thinner in consistency than other standard, milk-based formulas. This is typical for amino acid-based formulas, simply because the form of protein – amino acids – causes it to appear thinner in consistency. Before you add more powder, make sure you’re mixing Neocate correctly. Follow the directions on the can or check our mixing videos. If your doctor gives you special mixing instructions, please follow those instead.

Because amino acid-based infant formulas have a thin consistency, some parents have told us they noticed some extra spit up in first few days of starting Neocate. This typically improves over time. However, you should speak with your doctor about other solutions to minimize the spit ups.

Neocate smells and tastes different.

Wait, was that a question, or a statement? Because Neocate is uniquely made with amino acids, it also has a unique flavor. Some parents tell us that their baby doesn’t notice any change in taste, where for other babies, the difference can take time to get used to. If that’s the case, usually it just takes some time.

If you’re concerned that it’s taking too long for your infant to adjust to Neocate, please talk to her healthcare team for guidance. Before you do, we have developed a some handouts that may help you have that discussion. Look on this resources page for guides on Transitioning to Neocate and Feeding Tips for a Successful Transition.


We hope the answers to these questions help you when starting Neocate. As always, if you have questions about using the formula, please give our Nutrition Specialist team a call at 1-800-365-7354, Mo-Fr, 8:30am-5:00pm, ET.

-Christine Graham-Garo, Nutrition Specialist
-Rob McCandlish, RDN, Nutrition Specialist

Curious about how we know so much? Christine and Rob each have more than 5 years of experience at Nutricia. We talk to Neocate families and learn about the science behind Neocate and food allergies. Rob also has two nephews who used Neocate for cow milk allergies!

Published: 07/30/2013
Alexa Klein
Hi Dee, I'm glad to hear that Neocate has helped to resolve symptoms with your little one. Often times, it's a matter of time for many infants to adjust to Neocate's taste. This is similar to the unfamiliar taste of a new vegetable once an infant reaches solids, which research shows can take up to 15-20 times before they get used to the taste and accept it – it often takes a few days for them to adjust to Neocate. If your little one's intake continues to be lower than usual, please reach out to your pediatrician for additional guidance.
Hi my little girl had been prescribed all different milks that wasn’t working for her and she’s now on neocate which has worked her symptoms have completely gone but I have noticed she’s drinking 1oz every 3/4 hours now still having wet/dirty nappies she was taking 3oz before she’s only been on the milk 3 days is this normal is she getting used to it??
Hi Brianna, What you’re describing doesn’t sound unusual and is likely a result of the body adjusting to the way Neocate is digested and absorbed. If you have any concerns, it's best to follow up with your little one's doctor.
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