Neocate Information For Healthcare Providers

 
 

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Product Information

Explore Neocate's advanced line of evidence-backed hypoallergenic products that safely nourish patients with food allergy-related conditions from birth through school age and beyond.

 
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Neocate<sup>®</sup> Syneo<sup>®</sup> Infant
Neocate® Syneo® Infant

Neocate Syneo Infant is the first and only hypoallergenic formula with prebiotics and probiotics, specifically designed for infants with food allergies.

  • Hypoallergenic1
  • Backed by 4 clinical trials, clinically shown to:
    • Effectively relieves food allergy symptoms when used as part of dietary management2
    • Support growth and development1-5
    • Target gut dysbiosis and help balance the gut microbiota in infants with food allergies3-6
  • Based on 100% non-allergenic free amino acids
  • Nutritionally complete for infants 0-12 months
  • Shown in a clinical trial to help balance the gut microbiota to be more like that of healthy
    breastfed infants.*3
    • Probiotic Bifidobacterium breve M-16V
    • Prebiotic blend of scFOS and lcFOS

Neocate Syneo Infant is specially formulated for the dietary management of infants with cow milk allergy (CMA), multiple food allergies (MFA), and related gastrointestinal (GI) and allergic conditions, including eosinophilic GI disorders (EGIDs), food protein-induced enterocolitis syndrome (FPIES), and gastroesophageal reflux (GER) related to food allergies.

Good to Know

  • Added nucleotides & DHA/ARA
  • Dairy free
  • Made in a milk protein-free facility
  • No added soy oil
  • No artificial colors, flavors, or sweeteners
  • Kosher Pareve
  • Halal

Only Neocate Syneo Infant contains Syneo, a patented blend of prebiotics and probiotics, backed by years of research, and designed to help support a balanced gut microbiota in infants with food allergies. Until more data is available, Neocate Syneo Infant is not recommended for the following patients, for whom Neocate® Infant is still available, unless directed or supervised by a healthcare professional:

  • Infants with a post-pyloric feeding tube, which bypasses the stomach and empties into the small intestine.
  • Infants with a central venous catheter (CVC).
  • Infants with short bowel syndrome (SBS), unless a risk and benefit analysis is completed by a healthcare professional and the infant is monitored.
Neocate Syneo Infant should only be used under medical supervision.
Nutricia North America supports the use of breast milk wherever possible
scFOS = short-chain fructooligosaccharides; lcFOS = long-chain fructooligosaccharides
 
Features & Characteristics

Main Features

  • Osmolality: 360 m0sm/kg H2O*
  • Free water (at 0.67 kcal/mL): ~90%*
  • Energy distribution:
    • Protein: 11.5%
    • Carbohydrate: 44.7%
    • Fat (MCT 33%/LCT 67%): 43.8%
  • Potential renal solute load: 176 mOsm/L*
  • Displacement: 0.71 mL/g

Additional Details

Calories per 400 gram can (kcal) 1884
Calories per gram (kcal) 4.71
Grams/scoop (level, unpacked) 4.7
Calories/scoop (kcal) 22.1
Water displaced/gram (mL) 0.71
Water displaced/scoop (mL) 3.34
Protein Equivalent/scoop (g) 0.63
Protein Equivalent, g/100 mL* 1.9
Standard Dilution 20 kcal/fl oz
% Free Water* ~90.0%
Osmolality at 20 kcal/fl oz,* mOsm/kg H2O 360
Osmolality at 22 kcal/fl oz, mOsm/kg H2O 390
Osmolality at 24 kcal/fl oz, mOsm/kg H2O 420
Osmolality at 26 kcal/fl oz, mOsm/kg H2O 460
Osmolality at 27 kcal/fl oz, mOsm/kg H2O 490
Osmolality at 28 kcal/fl oz, mOsm/kg H2O 500
Osmolality at 30 kcal/fl oz, mOsm/kg H2O 550
Potential Renal Solute Load,* mOsm/L 176
Volume prepared formula per can* ~94 fl oz
Approximate scoops per can ~85
MCT:LCT ratio 33:67

*At standard dilution (20 kcal/fl oz) as listed above

Ordering & Reimbursement

Neocate Syneo Infant is available to healthcare professionals to sample. Contact your Nutricia sales representative to request samples to be sent free of charge to your practice.

Product Code Reimbursement Code HCPCS Code Product Packaging
127049 49735-0114-36 B4161 4 x 400 g (14.1 oz)

Neocate products are WIC† eligible in all states.

Reimbursement codes have been submitted by Nutricia North America to US data warehouses based on the format established by the data warehouses. These codes are not NDC numbers.

 

†WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants, and Children. WIC eligible means that a product has been approved at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area - fns.usda.gov/wic

Nutrition
NUTRIENTS PER 100 g PER 100 kcal (5 fl oz when prepared as directed)
Calories, kcal 471 100
Protein Equivalent, g 13.5 2.9
Carbohydrate, g 53.5 11.4
Soluble Fiber, g 4.3 0.9
Fat, g 23.0 4.9
Linoleic Acid, mg 3348 718

 

VITAMINS   PER 100 g PER 100 kcal (5 fl oz when prepared as directed)
Vitamin A, IU (mcg RE) 1365 (410) 290 (87.1)
Vitamin D3, IU (mcg) 367 (9.2) 77.9 (2.0)
Vitamin E, IU (mg α-TE) 7.9 (5.3) 1.7 (1.1)
Vitamin K, mcg 42.5 9.0
Thiamin, mcg 539 115
Riboflavin, mcg 540 115
Vitamin B6, mcg 540 115
Vitamin B12, mcg 1.3 0.28
Niacin, mcg 4904 1042
Folic Acid, mcg 63.8 13.5
Pantothenic Acid, mcg 2957 628
Biotin, mcg 19.1 4.1
Vitamin C, mg 51.6 11.0
Choline, mg 95.4 20.3
Inositol, mg 108 22.9

 

MINERALS   PER 100 g PER 100 kcal (5 fl oz when prepared as directed)
Calcium, mg 563 120
Phosphorus, mg 389 82.6
Magnesium, mg 49.6 10.5
Iron, mg 7.2 1.5
Zinc, mg 5.2 1.1
Manganese, mcg 198 42.1
Copper, mcg 406 86.2
Iodine, mcg 104 22.1
Molybdenum, mcg 11.0 2.3
Chromium, mcg 12.2 2.6
Selenium, mcg 14.2 3.0
Sodium, mg 188 39.8
Potassium, mg 512 109
Chloride, mg 372 78.9
Ingredients

Corn Syrup Solids, Refined Vegetable Oils (Medium Chain Triglycerides [Palm Kernel And/Or Coconut Oil], High Oleic Sunflower, Sunflower, And Canola Oils), Oligofructose, And Less Than 2% Of Each Of The Following: Inulin, Calcium Phosphate Dibasic, Dipotassium Phosphate, Tricalcium Phosphate, Calcium Carbonate, Calcium Glycerophosphate, L‑Arginine‑L‑Aspartate, L‑Leucine, Tripotassium Citrate, L‑Lysine Acetate, L‑Glutamine, L‑Proline, Citric Acid Esters Of Mono‑ And Diglycerides, L‑Valine, Glycine, L‑Isoleucine, L‑Threonine, L‑Phenylalanine, L‑Tyrosine, L‑Serine, L‑Histidine, L‑Alanine, Sodium Chloride, L‑Cystine, Magnesium Chloride, L‑Tryptophan, Choline Bitartrate, L‑Methionine, Tricalcium Citrate, Magnesium L‑Aspartate, M. alpina Oil,† Schizochytrium sp. Oil,‡ M‑Inositol, L‑Ascorbic Acid, Taurine, Ferrous Sulfate, Zinc Sulfate, L‑Carnitine, Niacinamide, Calcium D‑Pantothenate, Dl‑Alpha Tocopheryl Acetate, Bifidobacterium Breve M‑16V, Ascorbyl Palmitate, Manganese Sulfate, Thiamine Hydrochloride, Pyridoxine Hydrochloride, Cupric Sulfate, Riboflavin, Vitamin A Acetate, Dl‑Alpha Tocopherol, Potassium Iodide, Folic Acid, Mixed Tocopherols, Chromium Chloride, Phylloquinone, Sodium Selenite, Sodium Molybdate, D‑Biotin, Vitamin D3, Cyanocobalamin, Nucleotides (Disodium Uridine 5’‑Monophosphate, Cytidine 5’‑Monophosphate, Disodium Inosine 5’‑Monophosphate, Adenosine 5’‑Monophosphate, Disodium Guanosine 5’‑Monophosphate)

*A source of Arachidonic Acid (ARA)
**A source of Docosahexaenoic Acid (DHA)

Preparation & Storage

Information for Healthcare Professionals:

  • Neocate Syneo Infant can be given orally or by feeding tube. Not for parenteral use.
  • Tube feeding hang time: Nutricia recommends formula can be safely kept at room temperature for up to 4 hours, at which time unused formula should be discarded.
  • All scoops should be measured and unpacked. Use a scale that measures in grams for the most accurate results. Household measures are not recommended for measuring powdered Nutricia products.
Research & References

Growth in healthy infants & hypoallergenicity studies:1

Purposes: [1] To assess the hypoallergenicity of Neocate with synbiotics in IgE-mediated cow milk allergy, [2] To evaluate growth outcomes and formula tolerance in healthy infants fed Neocate with synbiotics. Methodology: [1] Thirty infants & children with IgE-mediated cow milk allergy used Neocate with synbiotics followed by a double-blind, placebo-controlled food challenge. [2] Healthy infants (0-15 days) were randomly assigned to receive a control amino acid-based formula or Neocate with synbiotics for 16 weeks. (n=115) Results/Conclusion: [1] This study demonstrated that Neocate with synbiotics is safe, well-tolerated and hypoallergenic according to American Academy of Pediatrics guidelines. [2] This study demonstrated that Neocate with synbiotics is safe, well tolerated and promotes normal growth when fed to healthy infants.

Read more on the studies 

Growth in infants with cow milk allergy study:2

Purpose: To evaluate growth outcomes and formula tolerance in infants with IgE- or non-IgE-mediated cow milk allergy fed Neocate with synbiotics. Methodology: Infants with cow milk allergy were randomly assigned to receive Neocate with synbiotics or a control formula (Neocate® Infant DHA/ARA) for 16 weeks. (n=110) Results/Conclusion: This study demonstrated that Neocate with synbiotics is safe and promotes normal growth in infants with cow milk allergy.

Read more on the study

Gut microbiota dysbiosis study over 8 weeks3:

Purpose: To determine whether Neocate Syneo Infant will improve the developing gut microbiota in infant subjects with cow milk allergy relative to a standard amino acid-based formula and healthy, breastfed infants. Methodology: Infants with non-IgE-mediated cow milk allergy were randomized to receive a control amino acid-based formula or Neocate Syneo Infant for 8 weeks. A healthy breastfed reference group was also included. Results/Conclusion: This study demonstrated that Neocate Syneo Infant helps balance the gut microbiota of infants with cow milk allergy, bringing it closer to that seen in age-matched, healthy breastfed infants (figures available).

Infants after 8 weeks of management with standard amino acid-based formula (control) or amino acid-based formula with pre- and probiotics (test) compared to age-matched, healthy, breastfed infants. At 8 weeks, levels of both bifidobacteria and Eubacterium rectale + Clostridium coccoides group were measured as a percentage of total fecal bacteria. Test group median levels were different than control group (p<0.001), and were closer to breastfed infant levels vs. control group.3

Read more on the study, including figures

Gut microbiota dysbiosis study over 26 weeks4:
Purpose: To determine whether Neocate Syneo Infant will improve the developing gut microbiota in infant subjects with cow milk allergy relative to a standard amino acid-based formula and healthy, breastfed infants over 26 days. Methodology: Infants with non-IgE-mediated cow milk allergy were randomized to receive a control amino acid-based formula or Neocate Syneo Infant for 26 weeks. A healthy breastfed reference group was also included. Results/Conclusion: At week 26 median percentages of bifidobacteria were significantly higher in test than control, whereas percentages of Eubacterium rectale/Clostridium coccoides were significantly lower. Safety parameters were similar between groups. Interestingly use of dermatological medication and reported ear infections were lower in test versus control. Beneficial effects of this AAF including specific synbiotics on microbiota composition were observed over 26 weeks, and shown suitable for dietary management of infants with non-IgE-mediated CMA.

Read more on the study, including figures

Gut microbiota diversity and metabolic activity study6

Purpose: To report the effects of an AAF including specific synbiotics on oral and gastrointestinal microbiota of infants with non-IgE mediated CMA with reference to healthy, breastfed infants. Methodology: Infants with suspected non-IgE mediated CMA received test or control formula. Test formula was AAF with synbiotics (prebiotic fructo-oligosaccharides and
probiotic Bifidobacterium breve M-16V). Control formula was AAF without synbiotics. Healthy, breastfed infants were used as a separate reference group. Results/Conclusion: The AAF including specific synbiotics effectively modulates the gut microbiota and its metabolic activity in non-IgE mediated CMA infants bringing it close to a healthy breastfed profile.

Read more on the study, including figures 

Research behind the Neocate portfolio of products:

Over 220 publications and counting support the use of Neocate for a wide variety of conditions and ages. Of those, there are more than 70 publications on the clinical use of Neocate formulas for the dietary management of cow milk allergy, multiple food allergies, and related GI and/or allergic conditions, including eosinophilic GI disorders (EGIDs), food protein-induced enterocolitis syndrome (FPIES), short bowel syndrome (SBS), malabsorption, and gastroesophageal reflux (GER) related to food allergies.

Healthcare professionals can review the science behind Neocate through the Nutricia Learning Center. Its easy and free to register for access to the following:

REFERENCES:

  1. Harvey BM, Langford JE, Harthoorn LF, et al. Effects on growth and tolerance and hypoallergenicity of an amino acid-based formula with synbiotics. Pediatr Res. 2014;75:343-51.
  2. Burks AW, Harthoorn LF, van Ampting MTJ, et al. Synbiotics-supplemented amino acid-based formula supports adequate growth in cow's milk allergic infants. Pediatr Allergy Immunol. 2015;26:316-22.
  3. Candy DCA, Van Ampting MTJ, Oude Nijhuis MM, et al. A synbiotic-containing amino-acid-based formula improves gut microbiota in non-IgE-mediated allergic infants. Pediatr Res. 2018;83:677-86.
  4. Fox, et al. Clin Transl Allergy. 2019;9:5.
  5. Chatchatee, et al. J Allergy Clin Immunol. 2022;149:650-8.e5.
  6. Wopereis, et al. Clin Transl Allergy. 2019;9:27.
Resources & Downloads

Healthcare professionals can access helpful information and resources online for Neocate Syneo Infant through the Nutricia Learning Center. It easy and free to register for access to the following:

  • Neocate Syneo infant transition guide
  • Approximate household measures (within mixing charts or the Neocate DRI Calculator and Mixing Tool)
  • Mixing charts 
  • Adding Neocate Syneo infant to human Milk
  • Neocate Calculator - Includes:
    • Neocate DRI calculator
    • Neocate mixing calculator
    • Calculate monthly need using kcal/day
  • Free CE-eligible webinars 
  • Dietary management flow charts

For patient safety, Nutricia directs parents and caregivers requesting specialized information, such as mixing instructions at non-standard dilutions, to their healthcare teams. Neocate should always be used under medical supervision.

Neocate<sup>®</sup> Infant
Neocate® Infant

Neocate Infant is a hypoallergenic amino acid-based formula1, designed for infants with food allergies and related gastrointestinal (GI) and/or allergic conditions.

  • Hypoallergenic2 – effectively relieves food allergy symptoms3
    • Based on 100% non-allergenic free amino acids
  • Nutritionally complete for infants 0-12 months – supports normal growth and development2,3

Neocate Infant is specially formulated for the dietary management of infants with cow milk allergy (CMA), multiple food allergies (MFA), and related GI and/or allergic conditions, including eosinophilic GI disorders (EGIDs), food protein-induced enterocolitis syndrome (FPIES), short bowel syndrome (SBS), malabsorption,* and gastroesophageal reflux (GER) related to food allergies.

Reassuring to Know

  • Added nucleotides & DHA/ARA
  • Dairy free
  • Made in a milk protein-free facility
  • No added soy oil
  • No artificial colors, flavors, or sweeteners
  • Kosher Pareve
  • Halal

*Malabsorption describes a diminished capacity for the body to sufficiently absorb and/or digest fat, protein, carbohydrate, and other nutrients from the diet to meet nutritional needs. Malabsorption can be due to either food allergy or non-food allergy-related conditions.

The causes of decreased nutrient absorption that may be present in infants and children with food allergies include reduced intestinal enzymes, reduced surface area of the small intestine, and/or the presence of gastrointestinal (GI) infection leading to mucosal damage. Additionally, GI signs and symptoms of bloody stools, vomiting, and diarrhea can lead to malabsorption, which could result in nutrient deficiencies and systemic manifestations such as poor growth.
Neocate® Infant DHA/ARA amino acid-based infant formula (AAF) can support the dietary management of malabsorption due to its composition. Neocate Infant DHA/ARA includes 33% of fat from medium-chain triglycerides (MCTs), 100% free amino acids, and corn syrup solids which are more easily absorbed than long-chain triglycerides (LCTs), whole proteins, and lactose, respectively. Neocate must be used under medical supervision. Routine monitoring of nutritional status, including calcium and phosphorus, is strongly recommended when AAF is used as primary or sole source of nutrition.

 
Features & Characteristics

Main Features:

Neocate Infant should only be used under medical supervision.

Nucleotides added (present in human milk4): 4.8 mg per 100 kcals

  • DHA at 0.37% fatty acids
  • DHA and ARA at 1:1 ratio
  • 340 mOsm/kg H2O*
  • Free water: ~90%*
  • Energy distribution:
    • Protein 11.1%
    • Carbohydrate 43.7%
    • Fat (MCT 33%/LCT 67%) 45.2%
  • Potential renal solute load: 177 mOsmol/L*
  • Displacement:0.70 mL/g

Additional Details:

Calories per 400 gram can (kcal) 1948
Calories per gram (kcal) 4.87
Grams/scoop (level, unpacked) 4.6
Calories/scoop (kcal) 22.4
Water displaced/gram (mL) 0.70
Water displaced/scoop (mL) 3.22
Protein Equivalent/scoop (g) 0.62
Protein Equivalent, g/100 mL* 1.9
Standard Dilution 20 kcal/fl oz
% Free Water* ~90%
Osmolality at 20 kcal/fl oz,* mOsm/kg H2O 340
Osmolality at 22 kcal/fl oz, mOsm/kg H2O 380
Osmolality at 24 kcal/fl oz, mOsm/kg H2O 410
Osmolality at 26 kcal/fl oz, mOsm/kg H2O 450
Osmolality at 27 kcal/fl oz, mOsm/kg H2O 470
Osmolality at 28 kcal/fl oz, mOsm/kg H2O 490
Osmolality at 30 kcal/fl oz, mOsm/kg H2O 530
Potential Renal Solute Load,* mOsm/L 177
Volume prepared formula per can* ~96 fl oz
Approximate scoops per can ~87
MCT:LCT ratio 33:67

*At standard dilution (20 kcal/fl oz), as listed above

Ordering & Reimbursement

Neocate Infant DHA/ARA is available to healthcare professionals to sample. Contact your Nutricia sales representative to request samples to be sent free of charge to your practice.

Product Code Reimbursement Code HCPCS Code Product Packaging
125626 49735-0125-95 B4161 4 x 400 g (14.1 oz)

Neocate products are WIC† eligible in all states.

Reimbursement codes have been submitted by Nutricia North America to US data warehouses based on the format established by the data warehouses. These codes are not NDC numbers.
†WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants, and Children. WIC eligible means that a product has been approved at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area- fns.usda.gov/wic
Nutrition
NUTRIENTS PER 100 g PER 100 kcal (5 fl oz when prepared as directed)
Calories 487 100
Protein Equivalent, g 13.5 2.8
Fat, g 24.5 5.0
   Linoleic Acid, mg 3565 732
Carbohydrate, g 52.0 10.7

 

VITAMINS PER 100 g PER 100 kcal (5 fl oz when prepared as directed)
Vitamin A, IU (mcg RE) 1352 (410) 280 (84.2)
Vitamin D3, IU (mcg) 367 (9.2) 75.3 (1.9)
Vitamin E, IU (mg α-TE) 7.9 (5.3) 1.6 (1.1)
Vitamin K, mcg 42.5 8.7
Thiamine, mcg 539 111
Riboflavin, mcg 540 111
Vitamin B6, mcg 539 111
Vitamin B12, mcg 1.3 0.27
Niacin, mcg 4904 1007
Folic Acid, mcg 63.8 13.1
Pantothenic Acid, mcg 2957 607
Biotin, mcg 19.1 3.9
Vitamin C, mg 51.6 10.6
Choline, mg 95.4 19.6
Inositol, mg 108 22.2

 

MINERALS PER 100 g PER 100 kcal (5 fl oz when prepared as directed)
Calcium, mg 576 118
Phosphorus, mg 396 81.3
Magnesium, mg 50.8 10.4
Iron, mg 7.4 1.1
Zinc, mg 5.4 1.1
Manganese, mcg 204 41.9
Copper, mcg 418 85.8
Iodine, mcg 104 21.4
Molybdenum, mcg 11.3 2.3
Chromium, mcg 12.6 2.6
Selenium, mcg 14.6 3.0
Sodium, mg 190 39
Potassium, mg 524 108
Chloride, mg 379 77.8

 

Ingredients

Corn Syrup Solids, Refined Vegetable Oils (Medium Chain Triglycerides [Palm Kernel And/Or Coconut Oil], High Oleic Sunflower, Sunflower, And Canola Oils), And Less Than 2% Of Each Of The Following: Calcium Phosphate Dibasic, Dipotassium Phosphate, Tricalcium Phosphate, Calcium Carbonate, Calcium Glycerophosphate, L‑Arginine‑L‑Aspartate, L‑Leucine, Tripotassium Citrate, L‑Lysine Acetate, L‑Glutamine, L‑Proline, Citric Acid Esters Of Mono‑ And Diglycerides, L‑Valine, Glycine, L‑Isoleucine, L‑Threonine, L‑Phenylalanine, L‑Tyrosine, L‑Serine, L‑Histidine, L‑Alanine, Sodium Chloride, L‑Cystine, Magnesium Chloride, L‑Tryptophan, Choline Bitartrate, L‑Methionine, Tricalcium Citrate, Magnesium L‑Aspartate, M. alpina Oil,† Schizochytrium sp. Oil,‡ M‑Inositol, L‑Ascorbic Acid, Taurine, Ferrous Sulfate, Zinc Sulfate, L‑Carnitine, Niacinamide, Calcium D‑Pantothenate, Dl‑Alpha Tocopheryl Acetate, Ascorbyl Palmitate, Manganese Sulfate, Thiamine Hydrochloride, Pyridoxine Hydrochloride, Cupric Sulfate, Riboflavin, Vitamin A Acetate, Dl‑Alpha Tocopherol, Potassium Iodide, Folic Acid, Mixed Tocopherols, Chromium Chloride, Phylloquinone, Sodium Selenite, Sodium Molybdate, D‑Biotin, Vitamin D3, Cyanocobalamin, Nucleotides (Disodium Uridine 5’‑Monophosphate, Cytidine 5’‑Monophosphate, Disodium Inosine 5’‑Monophosphate, Adenosine 5’‑Monophosphate, Disodium Guanosine 5’‑Monophosphate).

* A Source of Arachidonic Acid (ARA)
** A Source of Docosahexaenoic Acid (DHA)

Preparation & Storage

Information for Healthcare Professionals:

  • Neocate Infant DHA/ARA can be given orally or by feeding tube. Not for parenteral use.
  • Tube feeding hang time: Nutricia recommends formula can be safely kept at room temperature for up to 4 hours, at which time unused formula should be discarded.
  • All scoops should be measured and unpacked. Use a scale that measures in grams for the most accurate results. Household measures are not recommended for measuring powdered Nutricia products.
Research & References

Healthcare professionals can review the science behind Neocate through the Nutricia Learning Center. It's easy and free to register for access to the following:

  • A list of publications that mention the study or use of Neocate, including links to publicly available abstracts and full-text articles, where available  
  • Selected abstracts on key Neocate research 
  • Case studies on the use of Neocate 

REFERENCES:

  1. Sampson HA, James JM, Bernhisel-Broadbent J. Safety of an amino acid-derived infant formula in children allergic to cow milk. Pediatrics. 1992;90:463-5.
  2. Harvey BM, Langford JE, Harthoorn LF, et al. Effects on growth and tolerance and hypoallergenicity of an amino-acid based formula with synbiotics. Pediatr Res. 2014;75:343-51.
  3. Burks AW, Harthoorn LF, van Ampting MTJ, et al. Synbiotics-supplemented amino acid-based formula supports adequate growth in cow's milk allergic infants. Pediatr Allergy Immunol. 2015;26:316-22.
  4. Hodgkinson, et al. Nutr Res. 2022;99:13-24
Resources & Downloads

Healthcare professionals can access helpful information and resources online for Neocate Infant through the Nutricia Learning Center. It's easy and free to register for access to the following:

For patient safety, Nutricia directs parents and caregivers requesting specialized information, such as mixing instructions at non-standard dilutions, to their healthcare teams. Neocate should always be used under medical supervision.

Neocate<sup>®</sup> Nutra
Neocate® Nutra

Neocate® Nutra is the first and only hypoallergenic, solid food specifically designed for food allergic infants and children over six months of age. When mixed with water, Neocate® Nutra forms a smooth, cereal style consistency and is ideal for adding texture and variety to meals.

  • Hypoallergenic – effectively relieves food allergy symptoms
  • Based on 100% non-allergenic free amino acids

Neocate® Nutra is specially formulated for the dietary management of infants with cow milk allergy (CMA), multiple food allergies (MFA) and related GI and allergic conditions, including eosinophilic esophagitis (EoE), short bowel syndrome (SBS), malabsorption and gastroesophageal reflux (GER).

Good to Know

  • Dairy free
  • Made in a dairy protein-free facility
  • No added soy oil
  • No artificial colors, flavors, sweeteners or preservatives

For oral use only; not intended for bottle or tube feeding.

 
Features & Characteristics

Main Features:

  • Energy distribution:
    • Protein 7%
    • Carbohydrate 57%
    • Fat (MCT 4% / LCT 96%) 36%

Additional Details:

Calories per 37 gram sample packet (kcal) 175
Calories per 400 gram can (kcal) 1888
Calories per gram (kcal) 4.72
Grams/scoop (level, unpacked) 4.63
Calories/scoop (kcal) 21.8
Water displaced/gram (mL) N/A
Water displaced/scoop (mL) N/A
Protein Equivalent/scoop (g) 0.38
Number of suggested servings (8 scoops - 37 g) per can 10 servings
Number of half servings (4 scoops - 18.5 g) per can 21 half servings
Approximate scoops per can ~86
MCT:LCT ratio 4:96
n6:n3 ratio 10:1
Ordering & Reimbursement

Neocate® Nutra is available to healthcare professionals to sample in single-serving packets. Contact your Nutricia sales representative to request samples to be sent free of charge to your practice.

Product Code Reimbursement Code HCPCS Code Product Packaging
66739 49735-016739 B4161 4 x 400 g (14.1 oz)

WIC*: Contact your state WIC office to determine availability

Reimbursement codes have been submitted by Nutricia North America to US data warehouses based on the format established by the data warehouses. These codes are not NDC numbers.
WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants and Children. WIC eligible means that a product has been approved at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area.
Nutrition
NUTRIENTS PER 100 g PER SUGGESTED SERVING (37 g powder)*
Calories, kcal 472 175
Protein Equivalent, g 8.2 3.0
Fat, g 18.8 7.0
Linoleic Acid, mg 3222 1192
Carbohydrate, g 67.4 24.9

 

VITAMINS
Vitamin A, IU (mcg RE) 649 (195) 240 (72.2)
Vitamin D3, IU (mcg) 172 (4.3) 63.6 (1.6)
Vitamin E, IU (mg α-TE) 3.4 (2.3) 1.3 (0.84)
Vitamin K, mcg 18.5 6.8
Thiamin, mcg 250 90
Riboflavin, mcg 250 92.5
Vitamin B6, mcg 250 92.5
Vitamin B12, mcg 0.60 0.22
Niacin, mcg 1100 407
Folic Acid, mcg 27.5 10.2
Pantothenic Acid, mcg 1400 518
Biotin, mcg 9.1 3.4
Vitamin C, mg 23.0 8.5
Choline, mg 45.0 16.7
Inositol, mg 49.0 18.1

 

MINERALS
Calcium, mg (mEq) 668 (33.3) 247 (12.3)
Phosphorus, mg (mEq) 340 (21.9) 126 (8.1)
Magnesium, mg 21.0 7.8
Iron, mg 5.9 2.2
Zinc, mg 4.1 1.5
Manganese, mcg 310 115
Copper, mcg 310 115
Iodine, mcg 41.4 15.3
Molybdenum, mcg 8.8 3.3
Chromium, mcg 10.0 3.7
Selenium, mcg 11.3 4.2
Sodium, mg (mEq) 38.0 (1.7) 14.1 (0.61)
Potassium, mg (mEq) <20 (<0.51) <10 (<0.26)
Chloride, mg (mEq) 44 (1.2) 16.3 (0.46)

*37 g of powder provides one suggested serving when prepared as directed

Ingredients

Corn Syrup Solids (42%), Rice Starch (19%), Refined Vegetable Oil (18%) (Non-Hydrogenated Coconut (6%), High Oleic Sunflower (6%), Canola (3%), Sunflower (3%)), Sugar (9%), Calcium Phosphate Tribasic (2%), Contains 2% Or Less Than Each Of The Following: L-Arginine L-Aspartate, L-Leucine, L-Lysine Acetate, CAEM (An Emulsifier), L-Glutamine, L-Proline, L-Valine, Glycine, L-Isoleucine, L-Threonine, L-Phenylalanine, L-Tyrosine, L-Serine, L-Histidine, L-Alanine, L-Cystine, L-Tryptophan, L-Methionine, Choline Bitartrate, Magnesium L-Aspartate, Magnesium Acetate, M-Inositol, L-Ascorbic Acid, Ferrous Sulfate, Taurine, Zinc Sulfate, L-Carnitine, DL-Alpha Tocopheryl Acetate, Calcium D-Pantothenate, Niacinamide, Manganese Sulfate, Cupric Sulfate, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Riboflavin, Vitamin A Acetate, Potassium Iodide, Chromium Chloride, Folic Acid, Sodium Selenite, Sodium Molybdate, Phylloquinone, D-Biotin, Vitamin D3, Cyanocobalamin.

Preparation & Storage

Directions for Preparation and Use:

Total daily intakes for children and infants will vary depending on the age, body weight, and medical condition of the child.

  1. Wash hands thoroughly and clean the preparation area.
  2. Fill the scoop provided with Neocate® Nutra and level off. Do not press the powder into the scoop. Only use the scoop provided.
  3. Add the recommended number of scoops of Neocate® Nutra into a clean bowl.
  4. Gradually add the required amount of water while stirring with a clean spoon. Mix until thickened. To alter the consistency, add more or less water as required.

The suggested serving size is 8 scoops (37 g) of powder plus 2 fl oz of water to give a spoonable consistency. Other foods or formula must be consumed for a complete diet.

  AMOUNT OF NEOCATE® NUTRA POWDER AMOUNT OF WATER TO ADD FOR SPOONABLE CONSISTENCY
Suggested Serving 8 scoops or 37 g 2 fl oz
Half Serving 4 scoops or 18.5 g 1 fl oz

One can makes about 10 suggested servings or 21 half servings.

Neocate® Nutra should be prepared immediately prior to feeding. Any prepared product remaining should be discarded if not used within 1 hour. Neocate Nutra can be added to cooked dishes. Do not add to very hot foods. Do not warm prepared product.

Neocate® Nutra forms a smooth, spoonable consistency when mixed with water. Neocate Nutra is for oral use only and not intended to be used as a bottle or tube feed; not for parenteral use. Not suitable as a sole source of nutrition; Infants should also receive breast milk or hypoallergenic formula.

Storage:

Store unopened cans in a cool dry place. Once opened, reseal can. Store in a cool dry place (not a refrigerator) and use within one month.

Research & References

Over 150 publications and counting support the use of Neocate for a wide variety of conditions and ages. Of those, there are more than 60 publications on the clinical use of Neocate formulas for the dietary management of cow milk allergy, multiple food allergies and related gastrointestinal and allergic conditions, including eosinophilic esophagitis, short bowel syndrome, and gastroesophageal reflux. There are also many case studies that discuss the successful use of Neocate in these and other conditions, research studies that demonstrate the safe use of Neocate by otherwise healthy infants, and preclinical studies on Neocate.

Healthcare professionals can review the science behind Neocate through the Nutricia Learning Center. It’s easy and free to register for access to the following:

Resources & Downloads

Neocate® Nutra is the first and only hypoallergenic, solid food specifically designed for food allergic infants and children over six months of age. When mixed with water, Neocate® Nutra forms a smooth, cereal style consistency and is ideal for adding texture and variety to meals.

  • Hypoallergenic - effectively relieves food allergy symptoms
  • Based on 100% non-allergenic free amino acids

Neocate® Nutra is specially formulated for the dietary management of infants with cow milk allergy (CMA), multiple food allergies (MFA) and related GI and allergic conditions, including eosinophilic esophagitis (EoE), short bowel syndrome (SBS), malabsorption and gastroesophageal reflux (GER). 

Neocate<sup>®</sup> Junior
Neocate® Junior

Neocate® Junior is a hypoallergenic formula specifically designed to address the growing nutritional needs of individuals one year of age and older. Neocate® Junior, Vanilla, Strawberry, and Chocolate contain prebiotic fibers to help support digestive health.1-4 More than 55% of children do not meet their recommended fiber needs.5,6 To meet a variety of taste preferences, it comes in four flavors: Vanilla, Strawberry, Chocolate, and Unflavored.*

  • Hypoallergenic – effectively relieves food allergy symptoms
    • Based on 100% non-allergenic free amino acids
  • Nutritionally complete 
    • Neocate formulas for children 1 year and over have been shown in clinical trials to be effective in the dietary management of food allergies and to support normal growth7-9

Neocate Junior is specially formulated for the dietary management of those with cow milk allergy (CMA), multiple food allergies (MFA), and related gastrointestinal (GI) and/or allergic conditions, including eosinophilic GI disorders (EGIDs), food protein-induced enterocolitis syndrome (FPIES), short bowel syndrome (SBS), malabsorption, and gastroesophageal reflux (GER) related to food allergies.

Good to Know

  • Dairy free
  • No gluten added
  • No added soy oil
  • No artificial colors
  • Halal
  • Kosher Pareve (except Strawberry)

*Neocate® Junior, Unflavored does not contain prebiotic fibers.

 
Features & Characteristics

Main Features

  • Standard dilution = 1 kcal/mL
  • Energy distribution (Unflavored without prebiotics)
    • Protein 12.4%
    • Carbohydrate 42.6%
    • Fat (MCT 35% / LCT 65%) 45.0%
  • Energy distribution (Vanilla)
    • Protein 12.7%
    • Carbohydrate 43.1%
    • Fat (MCT 35% / LCT 65%) 44.2%
  • Energy distribution (Strawberry)
      • Protein 12.6%
      • Carbohydrate 43.2%
      • Fat (MCT 35% / LCT 65%) 44.2%
  • Energy distribution (Chocolate)
    • Protein 12.4%
    • Carbohydrate 44.2%
    • Fat (MCT 35% / LCT 65%) 43.4%

Additional Details

  Neocate Junior, Unflavored
(without prebiotics)		 Neocate Junior, Vanilla Neocate Junior, Strawberry Neocate Junior, Chocolate
Calories per 400 gram can (kcal) 1916 1872 1872 1828
Calories per gram (kcal) 4.79 4.68 4.68 4.57
Grams/scoop (level, unpacked) 7.3 7.3 7.3 7.5
Calories/scoop (kcal) 35.0 34.2 34.2 34.3
Water displaced/gram (mL) 0.69 0.70 0.70 0.70
Water displaced/scoop (mL) 5.04 5.11 5.11 5.25
Protein Equivalent/scoop (g) 1.1 1.1 1.1 1.1
Protein Equivalent, g/100 mL* 3.1 3.2 3.2 3.1
Standard Dilution 1 kcal/mL 1 kcal/mL 1 kcal/mL 1 kcal/mL
Approximate % Free Water* 85% 85% 85% 85%
Osmolality at 1 kcal/mL,* mOsm/kg H2O 600 620 610 660
Approximate volume per can* 64 fl oz 64 fl oz 64 fl oz 62 fl oz
Approximate scoops per can 55 55 55 53
MCT:LCT ratio 35:65 35:65 35:65 35:65
n6:n3 ratio 10:1 10:1 10:1 10:1

*At Standard Dilution, as listed above

Meets or exceeds 100% DRIs10,11 for protein + 25 key vitamins & minerals:

Ages 1-3 years 930 kcal
Ages 4-8 years 1370 kcal
Ages 9-13 years 1565 kcal
Ages 14-18 years 2550 kcal

 

Ordering & Reimbursement

Neocate Junior is available to healthcare professionals to sample. Contact your Nutricia sales representative to request samples to be sent free of charge to your practice.

  Product Code NDC-Format Code† / 
Reimbursement Code		 HCPCS Code Product Packaging
Unflavored (without prebiotics) 127048 49735-0117-90 B4161 or B4153 4 x 400 g (14.1 oz)
Vanilla 133282 49735-0106-27 B4161 or B4153 4 x 400 g (14.1 oz)
Strawberry 133280 49735-0164-56 B4161 or B4153 4 x 400 g (14.1 oz)
Chocolate 133283 49735-0126-90 B4161 or B4153 4 x 400 g (14.1 oz)
†Nutricia North America does not represent these codes to be National Drug Codes (NDCs). NDC-format codes are product codes adjusted according to standard industry practice to meet the format requirements of pharmacy and health insurance systems.
Nutrition

 

NUTRIENTS PER 100 mL* (100 kcal)
 Unflavored (without prebiotics) Vanilla Strawberry Chocolate
Calories, kcal 100 100 100 100
Protein Equivalent, g 3.1 3.2 3.2 3.1
Fat, g 5.0 4.9 4.9 4.8
Carbohydrate, g 10.7 11.0 11.0 11.3
Prebiotic Fiber, g 0 0.41 0.41 0.42
Vitamins 
Vitamin A, IU (mcg RE) 200 (60.0) 204 (61.3) 204 (61.3) 209 (62.9)
Vitamin D, IU (mcg) 79.4 (2.0) 81.2 (2.0) 81.1 (2.0) 83.2 (2.1)
Vitamin E, IU (mg α-TE) 2.1 (1.4) 2.1 (1.4) 2.1 (1.4) 2.2 (1.5)
Vitamin K, mcg 4.0 4.1 4.1 4.2
Thiamine, mg 0.10 0.10 0.10 0.11
Riboflavin, mg 0.20 0.21 0.20 0.21
Vitamin B6, mg 0.10 0.10 0.10 0.11
Vitamin B12, mcg 0.40 0.41 0.41 0.42
Niacin, mg 0.90 0.92 0.92 0.94
Folic acid, mcg 29.9 30.6 31.0 31.3
Pantothenic acid, mg 0.40 0.41 0.41 0.42
Biotin, mcg 3.0 3.1 3.1 3.2
Vitamin C, mg 9.3 9.5 9.5 9.8
Choline, mg 29.9 30.6 30.5 31.3
Inositol, mg 21.9 22.4 22.4 23.0
Minerals 
Calcium, mg 118 121 121 124
Phosphorus, mg 79.8 81.6 81.6 83.7
Magnesium, mg 16.0 16.3 16.3 16.8
Iron, mg 1.5 1.6 1.6 1.6
Zinc, mg 0.98 1.0 1.0 1.0
Manganese, mg 0.13 0.13 0.13 0.14
Copper, mcg 111 113 113 116
Iodine, mcg 17.8 18.2 18.2 18.7
Molybdenum, mcg 4.5 4.6 4.6 4.7
Chromium, mcg 3.8 3.8 3.8 3.9
Selenium, mcg 4.0 4.1 4.1 4.2
Sodium, mg 50.0 51.1 51.0 52.3
Potassium, mg 136 140

139

 143
Chloride, mg 76.1 77.8 77.7 79.7

*Standard dilution = 1 kcal/mL

Ingredients

Unflavored (without prebiotics):
Corn Syrup Solids, Refined Vegetable Oil (Medium Chain Triglycerides (Palm Kernel and/or Coconut Oil), High Oleic Sunflower Oil, Canola Oil, Sunflower Oil), L-Serine, and less than 2% of each of the following: L-Glutamine, Glycine, L-Alanine, L-Leucine, L-Lysine Acetate, L-Threonine, L-Tyrosine, Dipotassium Phosphate, Citric Acid Esters of Mono- and Diglycerides, L-Valine, Tricalcium Phosphate, Maltodextrin, L-Isoleucine, Tripotassium Citrate, Trisodium Citrate, Calcium Carbonate, L-Proline, L-Cystine, L-Histidine, L-Phenylalanine, Choline Bitartrate, Magnesium Hydrogen Phosphate, L-Methionine, L-Arginine, Sodium Chloride, Calcium Chloride, L-Tryptophan, Magnesium Chloride, M-Inositol, L-Ascorbic Acid, Sunflower Lecithin, Taurine, Ferrous Sulfate, L-Carnitine, Zinc Sulfate, DL-Alpha Tocopheryl Acetate, Ascorbyl Palmitate, Niacinamide, Calcium D-Pantothenate, Manganese Sulfate, Cupric Sulfate, Riboflavin, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Vitamin A Acetate, Folic Acid, Potassium Iodide, Chromium Chloride, Sodium Molybdate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D3, Cyanocobalamin.

Vanilla:
Corn Syrup Solids, Refined Vegetable Oil (Medium Chain Triglycerides (Palm Kernel and/or Coconut Oil), High Oleic Sunflower Oil, Canola Oil, Sunflower Oil), L-Serine, and less than 2% of each of the following: L-Glutamine, Glycine, L-Alanine, L-Leucine, L-Lysine Acetate, L-Threonine, Artificial Flavor, L-Tyrosine, Dipotassium Phosphate, Fructooligosaccharides, Inulin, L-Valine, Citric Acid Esters of Mono- and Diglycerides, Tricalcium Phosphate, Maltodextrin, L-Isoleucine, Tripotassium Citrate, Trisodium Citrate, Calcium Carbonate, L-Proline, L-Cystine, L-Histidine, L-Phenylalanine, Choline Bitartrate, Magnesium Hydrogen Phosphate, L-Methionine, L-Arginine, Sodium Chloride, Calcium Chloride, L-Tryptophan, Magnesium Chloride, M-Inositol, L-Ascorbic Acid, Sunflower Lecithin, Sucralose, Taurine, Ferrous Sulfate, L-Carnitine, Zinc Sulfate, DL-Alpha Tocopheryl Acetate, Ascorbyl Palmitate, Niacinamide, Calcium D-Pantothenate, Manganese Sulfate, Cupric Sulfate, Riboflavin, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Vitamin A Acetate, Folic Acid, Potassium Iodide, Chromium Chloride, Sodium Molybdate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D3, Cyanocobalamin.

Strawberry:
Corn Syrup Solids, Refined Vegetable Oil (Medium Chain Triglycerides (Palm Kernel and/or Coconut Oil), High Oleic Sunflower Oil, Canola Oil, Sunflower Oil), L-Serine, and less than 2% of each of the following: L-Glutamine, Glycine, L-Alanine, L-Leucine, L-Lysine Acetate, L-Threonine, Artificial Flavor, L-Tyrosine, Dipotassium Phosphate, Fructooligosaccharides, Inulin, L-Valine, Citric Acid Esters of Mono- and Diglycerides, Tricalcium Phosphate, Maltodextrin, L-Isoleucine, Tripotassium Citrate, Trisodium Citrate, Calcium Carbonate, L-Proline, L-Cystine, L-Histidine, L-Phenylalanine, Choline Bitartrate, Magnesium Hydrogen Phosphate, L-Methionine, L-Arginine, Sodium Chloride, Calcium Chloride, L-Tryptophan, Magnesium Chloride, M-Inositol, L-Ascorbic Acid, Citric Acid, Sunflower Lecithin, Sucralose, Taurine, Ferrous Sulfate, L-Carnitine, Zinc Sulfate, DL-Alpha Tocopheryl Acetate, Ascorbyl Palmitate, Niacinamide, Calcium D-Pantothenate, Manganese Sulfate, Cupric Sulfate, Riboflavin, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Vitamin A Acetate, Folic Acid, Potassium Iodide, Chromium Chloride, Sodium Molybdate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D3, Cyanocobalamin.

Chocolate:
Corn Syrup Solids, Refined Vegetable Oil (Medium Chain Triglycerides (Palm Kernel and/or Coconut Oil), High Oleic Sunflower Oil, Canola Oil, Sunflower Oil),  Artificial Flavors, L-Serine, and less than 2% of each of the following: L-Glutamine, Glycine, L-Alanine, L-Leucine, L-Lysine Acetate, L-Threonine, Dipotassium Phosphate, L-Tyrosine, Fructooligosaccharides, Inulin, L-Valine, Citric Acid Esters of Mono- and Diglycerides, Tricalcium Phosphate, Maltodextrin, L-Isoleucine, Tripotassium Citrate, Trisodium Citrate, Calcium Carbonate, L-Proline, L-Cystine, L-Histidine, L-Phenylalanine, Choline Bitartrate, Magnesium Hydrogen Phosphate, L-Methionine, L-Arginine, Sodium Chloride, Calcium Chloride, L-Tryptophan, Magnesium Chloride, M-Inositol, L-Ascorbic Acid, Sunflower Lecithin, Sucralose, Taurine, Ferrous Sulfate, L-Carnitine, Zinc Sulfate, DL-Alpha Tocopheryl Acetate, Niacinamide, Ascorbyl Palmitate, Calcium D-Pantothenate, Manganese Sulfate, Cupric Sulfate, Riboflavin, Thiamin Chloride Hydrochloride, Pyridoxine Hydrochloride, Vitamin A Acetate, Folic Acid, Potassium Iodide, Chromium Chloride, Sodium Molybdate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D3, Cyanocobalamin.

Preparation & Storage

Directions for Preparation and Use:

For use only under medical supervision. Suitable for use as a supplement or sole source of nutrition for those one year of age and older. Suggested intake to be determined by a healthcare professional and is dependent on the age, body weight, and medical condition of the individual. For oral and tube feeding only; not for parenteral use.

To make at standard dilution (1 kcal/mL):

  1. Wash hands thoroughly and clean the preparation area.
  2. Pour the required amount of water into container.
  3. Add 1 unpacked, level scoop of powder (7.5 g) to each 1 fl oz of water.
  4. Stir, or cover and shake, until the powder has dissolved. Feed OR refrigerate immediately and use within 24 hours. Once feeding begins, use within 1 hour or discard.

If taken orally, Neocate Junior is best served chilled.

Do not boil or use a microwave to warm formula; serious burns may result.

Storage: Store unopened or opened can in a cool, dry place. Once opened, replace can lid and use within 1 month. Do not store at extreme temperatures.

Research & References

Over 220 publications and counting support the use of Neocate in a wide variety of conditions and ages. Of those, several publications report the clinical use of Neocate formulas for the dietary management of cow milk allergy, multiple food allergies, and related gastrointestinal (GI) and/or allergic conditions, including eosinophilic GI disorders, food protein-induced enterocolitis syndrome, short bowel syndrome, and gastroesophageal reflux related to food allergies. 

Healthcare professionals can review the science behind Neocate and access helpful information and resources through the Nutricia Learning Center. It’s easy and free to register for access to the following:

For patient safety, Nutricia directs caregivers requesting specialized information, such as mixing instructions at non-standard dilutions, to their healthcare teams. Neocate should always be used under medical supervision.

REFERENCES:

  1. Elia M, Engfer MB, Green CJ, et al. Systematic review and meta-analysis: the clinical and physiological effects of fibre-containing enteral formulae. Aliment Pharmacol Ther. 2008;27:120-45.
  2. Cummings JH. Prebiotics and the gut barrier to infection. J Pediatr Gastroenterol Nutr. 2004;39:S555.
  3. Brownawell AM, Caers W, Gibson GR, et al. Prebiotics and the health benefits of fiber: current regulatory status, future research, and goals. J Nutr. 2012;142:962-74.
  4. Bosscher D, Van Loo J, Franck A. Inulin and oligofructose as prebiotics in the prevention of intestinal infections and diseases. Nutr Res Rev. 2006;19:216-26.
  5. Butte NF, Fox MK, Briefel RR, et al. Nutrient intakes of US infants, toddlers, and preschoolers meet or exceed dietary reference intakes. J Am Diet Assoc. 2010;110:S27-37.
  6. Hampl JS, Betts NM, Benes BA. The 'age+5' rule: comparisons of dietary fiber intake among 4- to 10-year-old children. J Am Diet Assoc. 1998;98:1418-23.
  7. Isolauri E, Sampson HA. Use of an amino acid based formula in the management of cow’s milk allergy and multiple food protein intolerance in children. J Allergy Clin Immunol. 2004;113:S154(518).
  8. Berni Canani R, Nocerino R, Frediani T, et al. Amino acid-based formula in cow's milk allergy: long-term effects on body growth and protein metabolism. J Pediatr Gastroenterol Nutr. 2017;64:632-8.
  9. Sorensen K, Fry C, Allford A, et al. Longitudinal study shows improved nutrient intakes and growth with an amino acid formula for children ≥1y with cow's milk allergy and related conditions. Poster presented at EAACI Annual Congress. Jun 17-21; Helsinki, Finland. Poster at EAACI Annual Congress. 2017.
  10. Food and Nutrition Board, Institute of Medicine; Otten JJ, Hellwig JP, Meyers LD, Eds. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Institute of Medicine (IOM) of the National Academies, Washington, DC: National Academies Press; 2006.
  11. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, et al, Eds. Dietary reference intakes for calcium and vitamin D. Institute of Medicine (IOM) of the National Academies, Washington, DC: National Academies Press; 2011.
Resources & Downloads
Neocate<sup>®</sup> Splash
Neocate® Splash

Neocate Splash is the first and only ready-to-feed hypoallergenic formula specifically designed to address the growing nutritional and lifestyle needs of toddlers, older children, and teens. Neocate Splash has a similar nutritional composition to Neocate® Junior and is ideal for oral and tube feeding. To meet a variety of taste preferences, it comes in five flavors: vanilla, orange-pineapple, grape, tropical fruit, and unflavored.

  • Hypoallergenic- effectively relieves food allergy symptoms
    • Based on 100% non-allergenic free amino acids
  • Nutritionally complete for toddlers, older children, and teens
    • Neocate formulas for children 1 year and over have been shown in clinical trials to be effective in the dietary management of food allergies and to support normal growth1-3
  • Convenient ready-to-feed 8 fl oz drink boxes

Neocate Splash is specially formulated for the dietary management of children with cow milk allergy (CMA), multiple food allergies (MFA), and related gastrointestinal and allergic conditions, including eosinophilic esophagitis (EoE), food protein-induced enterocolitis syndrome (FPIES), gastroesophageal reflux (GER), short bowel syndrome (SBS), and malabsorption.

Good to Know

  • Sterile liquid, ideal for in- and outpatient use
  • No added soy oil
  • Gluten free
  • No artificial colors
 
Features & Characteristics

Main Features

  • Energy distribution:
    • Protein                                         12%
    • Carbohydrate                          42%
    • Fat (MCT 35%/LCT 65%)  46%

Additional Details

Volume per drink box
 8 fl oz
237 mL
Calories per drink box (kcal) 237
Protein Equivalent, g/100 mL 3.0
Standard Dilution 30 kcal/fl oz
(1.0 kcal/mL)
% Free Water 84.6%
Osmolality, mOsm/kg H2O Unflavored - 670
Grape - 740
Orange-Pineapple - 790
Tropical Fruit - 790
Vanilla - 710
MCT:LCT ratio 35:65

 

Meets or exceeds 100% DRIs4,5 for protein + 25 key vitamins & minerals: 
Ages 1-3 years 930 mL
Ages 4-8 years 1370 mL
Ages 9-13 years 1565 mL
Ages 14-18 years 2550 mL

 

Ordering & Reimbursement

Neocate Splash is available to healthcare professionals to sample. Contact your Nutricia sales representative to request samples to be sent free of charge to your practice.

  Product Code Reimbursement Code HCPCS Code Product Packaging
Unflavored 111394 49735-0144-51 B4161 or B4153 27 x 237 mL (8 fl oz)
Grape 122435 49735-0124-35 B4161 or B4153 27 x 237 mL (8 fl oz)
Orange-Pineapple 122436 49735-0124-36 B4161 or B4153 27 x 237 mL (8 fl oz)
Tropical Fruit 122437 49735-0124-37 B4161 or B4153 27 x 237 mL (8 fl oz)
Vanilla 176678 49735-0100-59 B4161 or B4153 27 x 237 mL (8 fl oz)

WIC*: Neocate products are WIC† eligible in all states.

Reimbursement codes have been submitted by Nutricia North America to US data warehouses based on the format established by the data warehouses. These codes are not NDC numbers.
†WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants, and Children. WIC eligible means that a product has been approved at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area – fns.usda.gov/wic
Nutrition
Nutrients PER 100 mL PER DRINK BOX (8 fl oz / 237 mL)
Calories, kcal 100 237
Protein Equivalent, g 3.0 7.1
Fat, g 5.1 12.1
   Linoleic Acid, mg (unflavored) 325 (292) 769 (691)
Carbohydrate, g 10.5 24.9

 

Vitamins  
Vitamin A, IU (mcg RE) 200 (60.0) 474 (142)
Vitamin D3, IU (mcg) 80.0 (2.0) 190 (4.7)
Vitamin E, IU (mg α-TE) 2.1 (1.4) 5.0 (3.3)
Vitamin K, mcg 4.0 9.5
Thiamine, mg 0.10 0.24
Riboflavin, mg 0.20 0.47
Vitamin B6, mg 0.10 0.24
Vitamin B12, mcg 0.40 0.95
Niacin, mg 0.90 2.1
Folic Acid, mcg 29.9 70.9
Pantothenic Acid, mg 0.40 0.95
Biotin, mcg 3.0 7.1
Vitamin C, mg 9.3 22.0
Choline, mg 29.9 70.9
Inositol, mg 22.0 52.1

 

Minerals  
Calcium, mg (mEq) 118 (5.9) 280 (14.0)
Phosphorus, mg (mEq) 80.0 (5.2) 190 (12.3)
Magnesium, mg 16.0 37.9
Iron, mg 1.5 3.6
Zinc, mg 0.98 2.3
Manganese, mg 0.13 0.31
Copper, mcg 100 237
Iodine, mcg 17.8 42.2
Molybdenum, mcg 4.5 10.7
Chromium, mcg 3.8 9.0
Selenium, mcg 4.0 9.5
Sodium, mg 60.0 142
Potassium, mg (mEq) 137 (3.5) 325 (8.3)
Chloride, mg (mEq) 76.0 (2.1) 180 (5.1)

 

Ingredients

Water, Maltodextrin, Sugar, Refined Vegetable Oils (High Oleic Sunflower Oil, Medium Chain Triglycerides (Modified Palm Kernel And/Or Coconut Oil), Canola Oil), And Less Than 2% of each of the following: Calcium Glycerophosphate, Malic Acid, L-Arginine, L-Lysine L-Aspartate, Microcrystalline Cellulose, L-Leucine, Tripotassium Citrate, L-Phenylalanine, Diacetyl Tartaric Acid Esters Of Mono- And Diglycerides, Mono- And Diglycerides, Trisodium Citrate, L-Proline, L-Valine, Glycine, L-Isoleucine, N-Acetyl, L-Methionine, L-Threonine, L-Histidine, L-Serine, L-Alanine, Potassium Chloride, Magnesium Acetate, Choline Bitartrate, L-Tryptophan, Calcium Chloride, L-Tyrosine, Cellulose Gum, L-Ascorbic Acid, M-Inositol, L-Cystine, Taurine, L-Carnitine, Zinc Sulfate, Dl-Alpha Tocopheryl Acetate, Niacinamide, Calcium D-Pantothenate, Manganese Sulfate, Sodium Selenite, Cupric Sulfate, Riboflavin, Chromium Chloride, Thiamine Chloride Hydrochloride, Vitamin A Palmitate, Pyridoxine Hydrochloride, Folic Acid, Potassium Iodide, Sodium Molybdate, Phylloquinone, D-Biotin, Vitamin D3, Cyanocobalamin.

Unflavored also contains less than 2% of: Ferrous Sulfate.

Grape also contains less than 2% of: Artificial Flavors, Sucralose, Ferrous Lactate.

Tropical Fruit also contains less than 2% of: Artificial Flavor, Acesulfame Potassium, Ferrous Lactate.

Orange-Pineapple also contains less than 2% of: Artificial Flavors, Sucralose, Ferrous Lactate.

Vanilla also contains less than 2% of: Artificial Flavors, Sucralose, Ferrous Lactate.

Preparation & Storage

Directions for Preparation and Use:

The suggested intake should be determined by a healthcare professional and is dependent on the age, body weight, and medical condition of the patient. Neocate Splash provides complete or supplemental nutritional support for those over 1 year of age. Use under medical supervision. For oral and tube feeding only; not for parenteral use.

Shake well before use. If taken orally, Neocate Splash is best served chilled. Once the drink box is opened, formula can be stored in a refrigerator and kept no longer than 24 hours from the time of opening. Discard formula left in drink box, cup, or bottle 1 hour after feeding starts. Do not freeze, boil, or use a microwave to warm Neocate Splash.

Storage:

Store unopened product in a cool, dry place. Once opened, Neocate® Splash should be stored in a refrigerator and kept no longer than 24 hours.

Research & References

Over 210 publications and counting support the use of Neocate for a wide variety of conditions and ages. Of those, there are more than 70 publications on the clinical use of Neocate formulas for the dietary management of cow milk allergy, multiple food allergies and related gastrointestinal and allergic conditions, including eosinophilic esophagitis, short bowel syndrome, and gastroesophageal reflux. There are also many case studies that discuss the successful use of Neocate in these and other conditions, and preclinical studies on Neocate.

Healthcare professionals can review the science behind Neocate through the Nutricia Learning Center. It’s easy and free to register for access to the following:

REFERENCES:

  1. Isolauri E, Sampson HA. Use of an amino acid based formula in the management of cow’s milk allergy and multiple food protein intolerance in children. J Allergy Clin Immunol. 2004;113:S154(518).
  2. Berni Canani R, Nocerino R, Frediani T, et al. Amino acid-based formula in cow's milk allergy: long-term effects on body growth and protein metabolism. J Pediatr Gastroenterol Nutr. 2017;64:632-8.
  3. Sorensen K, Fry C, Allford A, et al. Longitudinal study shows improved nutrient intakes and growth with an amino acid formula for children ≥1y with cow's milk allergy and related conditions. Poster presented at EAACI Annual Congress. Jun 17-21; Helsinki, Finland. Poster at EAACI Annual Congress. 2017.
  4. Food and Nutrition Board, Institute of Medicine; Otten JJ, Hellwig JP, Meyers LD, Eds. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Institute of Medicine (IOM) of the National Academies, Washington, DC: National Academies Press; 2006.
  5. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, et al, Eds. Dietary reference intakes for calcium and vitamin D. Institute of Medicine (IOM) of the National Academies, Washington, DC: National Academies Press; 2011.
Resources & Downloads

Healthcare professionals can access helpful information and resources online for Neocate Splash through the Nutricia Learning Center. It’s easy and free to register for access to the following:

For patient safety, Nutricia directs parents and caregivers requesting specialized information, such as mixing instructions at non-standard dilutions, to their healthcare teams. Neocate should always be used under medical supervision.

Duocal<sup>®</sup>
Duocal®

A powdered medical food providing fat and carbohydrate for increased caloric intake. Super soluble without altering the taste or texture of foods and beverages

Duocal® offers ideal support for children who need extra calories that can support vibrant health and catch-up growth.

  • Calorically dense – 1 scoop (5 g)provides 25 kcal
  • Mixes easily in liquids and soft foods

Duocal® is specially formulated for the dietary management of conditions where a high-energy, low-fluid, low-electrolytes diet is indicated, protein-restricted diets, disorders of protein and amino acid metabolism, malabsorptive states, modular diets, and catabolic states (e.g. burns, trauma, post-operative stress).

It contains a unique dual energy source of carbohydrate and fat (no protein, vitamins or minerals). Duocal® is flavorless and is suitable for oral and tube feeding.

Good to Know

  • Milk protein-free
  • Made in a dairy protein-free facility
  • No protein added
  • No artificial colors, flavors, sweeteners or preservatives
  • Kosher Pareve

Duocal is not nutritionally complete. Not suitable for use as a sole source of nutrition. It is to be added to foods or formulas in order to add extra calories into the diet. Not for parenteral use.

Duocal® is a specially formulated medical food and should only be used under medical supervision.
 
Features & Characteristics
Calories per 400 gram can (kcal) 1968
Calories per gram (kcal) 4.92
Displacement, mL/g 0.77
Osmolality (1:3 dilution), mOsm/kg H2O 310
Milliosmoles contributed by 1 gram of Duocal® added to a solution 0.93
PRSL, mOsm/g < 0.017
Percent total energy from carbohydrate 59%
Percent total energy from fat 41%
MCT:LCT ratio 50:50
Ordering & Reimbursement

Duocal® is available to healthcare professionals to sample. Contact your Nutricia sales representative to request samples to be sent free of charge to your practice.

Product Code Reimbursement Code HCPCS Code Product Packaging
49828 49735-0182-62 B4155 6 x 400 g (14.1 oz)

WIC*: Contact your state WIC office to determine availability

Reimbursement codes have been submitted by Nutricia North America to US data warehouses based on the format established by the data warehouses. These codes are not NDC numbers.
*WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants and Children. WIC eligible means that a product has been approved at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area.
Nutrition
NUTRIENTS PER 100 G
Calories, kcal 492
Protein, g 0
Fat, g 22.3
Saturated, g 13.8
Monounsaturated, g 2.5
Polyunsaturated, g 4.8
Carbohydrate, g 72.7

 

MINERALS
Sodium, mg ≤ 20.0
Potassium, mg ≤ 5.0
Chloride, mg ≤ 20.0
Calcium, mg ≤ 5.0
Phosphorus, mg ≤ 5.0
Ingredients

Corn Syrup Solids, Refined Vegetable Oils (Corn, Non-Hydrogenated Coconut, Modified Coconut and/or Palm Kernel Oil (Medium Chain Triglycerides)), Mono- and Diglycerides, Diacetyl Tartaric Acid Esters of Mono- and Diglycerides.

Preparation & Storage

Directions for Preparation and Use:

The amount of Duocal® to take should be determined by a healthcare professional and is dependent on the age, body weight and medical condition. Duocal provides extra energy for children over 1 year of age. Use under medical supervision. For oral and tube feeding only; not for parenteral use. Duocal® intake should be distributed throughout the day, beginning with approximately 1 scoop per ½ cup of food or beverage and progressing as high as 4 scoops per ½ cup of food or beverage, under the guidance of a healthcare professional.

For oral or tube feeding:

  1. Measure the prescribed amount of Duocal®.
  2. Add powder to the required volume of liquid and/or soft food and stir continuously until the powder has dissolved.
  3. Unused foods mixed with Duocal® should be refrigerated and used within 24 hours. Shake or stir immediately before serving.

Duocal® is simple to use, is completely soluble and mixes easily in liquids and moist foods.

Storage:

Store unopened can at room temperature. Once opened, reseal can and store in a cool, dry place (not in refrigerator) and use within one month.

Research & References

Over 20 publications suggest or mention the use of Duocal® products in clinical settings by children and adults with increased energy needs.

Resources & Downloads

Healthcare professionals can access helpful information and resources online for Duocal® through the Nutricia Learning Center. It’s easy and free to register for access to the following:

  • Duocal® Calculator - Includes: 
    • Concentration charts for adding Duocal® to enteral formula
    • Duocal mixing calculator - for adding Duocal® to enteral formula
    • Household measures calculator

For patient safety, Nutricia directs parents and caregivers requesting specialized information, such as custom mixing instructions or household measures, to their healthcare teams.

Phlexy-Vits
Phlexy-Vits

A concentrated, powdered vitamin, mineral and trace element preparation designed to help meet the micronutrient requirements of older children (11 years and older) and adults. One 7 g packet supplies the majority of vitamins and minerals needed to meet the DRI of individuals 11 years and older.

Phlexy-Vits is specially formulated for the dietary management of conditions with restrictive therapeutic diets.

Good to Know

  • Made in a dairy protein-free facility
  • No artificial colors, flavors, sweeteners

Use under medical supervision. Not suitable for use as a sole source of nutrition. Not for parenteral use.

Phlexy-Vits is a specially formulated medical food and should only be used under medical supervision.
 
Features & Characteristics
Calories per 7 gram packet (kcal) 0.2
Osmolality (1:6 dilution, mixed to 50 mL), mOsm/kg H2O 733
Milliosmoles contributed by 1 packet (7 g) of Phlexy-Vits® added to a solution 31.5
Milliosmoles contributed by 1 gram of Phlexy-Vits® added to a solution 4.5
Ordering & Reimbursement
Product Code Reimbursement Code HCPCS Code Product Packaging
49133 49735-0106-85 A9270 30 x 7 g
Reimbursement codes have been submitted by Nutricia North America to US data warehouses based on the format established by the data warehouses. These codes are not NDC numbers.
Nutrition
NUTRIENTS PER 7 g PACKET
Calories, kcal 0.20
Protein, g 0.02
Fat, g None
Carbohydrate, g 0.04

 

VITAMINS PER 7 g PACKET
Vitamin A, IU (mcg RE) 2664 (800)
Vitamin D, IU (mcg) 400 (10)
Vitamin E, IU (mg α-TE) 13.5 (9)
Vitamin K, mcg 70.0
Thiamin, mg 1.2
Riboflavin, mg 1.4
Vitamin B6, mg 1.6
Vitamin B12, mcg 5.0
Niacin, mg 20.0
Folic Acid, mcg 700
Pantothenic Acid, mg 5.0
Biotin, mcg 150
Vitamin C, mg 50.0

 

MINERALS PER 7 g PACKET
Calcium, mg 1000
Phosphorus, mg 775
Magnesium, mg 300
Iron, mg 15.1
Zinc, mg 11.1
Manganese, mg 1.5
Copper, mcg 1505
Iodine, mcg 150
Molybdenum, mcg 70.0
Chromium, mcg 30.0
Selenium, mcg 75.0
Sodium, mg 8.8
Potassium, mg <1.4
Chloride, mg <0.35
Ingredients

Calcium Phosphate Dibasic, Magnesium Acetate, Guar Gum, L-Ascorbic Acid, Ferrous Sulfate, Dextrose, Zinc Sulfate, Nicotinamide, DL-Alpha Tocopheryl Acetate, Copper Gluconate, Calcium D-Pantothenate, Manganese Sulfate, Pyridoxine Hydrochloride, Thiamin Mononitrate, Riboflavin, Vitamin A Acetate, Folic Acid, Potassium Iodide, Sodium Molybdate, Sodium Selenite, D-Biotin, Chromium Chloride, Phylloquinone, Vitamin D3, Cyanocobalamin.

Preparation & Storage

Directions for Preparation and Use:

The amount of Phelxy-Vits to take should be determined by a healthcare professional and is dependent on the age, body weight and medical condition of the patient. Phlexy-Vits provides supplemental nutritional support for older children (from approximately 11 years) and adults, and is not intended as the sole source of nutrition. Must only be given under strict medical supervision. For oral and tube feeding only; not for parenteral use. Not recommended for infants and young children.

  1. Mix one packet of Phlexy-Vits to a smooth paste with a small amount of water, lemonade, fruit juice or other beverage (approx. 1.5 fl oz or 45 mL).
  2. Dilute with additional liquid to a final volume of 5 fl oz (150 mL). The amount of liquid used will vary according to taste.

Natural discoloration of this product can occur after reconstitution. For best results, consume immediately. 

Storage:

Store in a cool, dry place. Once opened, a packet should be stored in an airtight container and used within 2-3 days.

Resources & Downloads

Healthcare professionals can access helpful information and resources online for Phlexy-Vits® through the Nutricia Learning Center. It’s easy and free to register for access to the following:

For patient safety, Nutricia directs parents and caregivers requesting specialized information, such as household measures, to their healthcare teams.

Essential Amino Acid Mix
Essential Amino Acid Mix

Essential Amino Acid Mix is an unflavored, powdered mixture of essential amino acids, including cystine and histidine. A medical food.

  • Balanced mixture of essential amino acids

Essential Amino Acid Mix is specially formulated for use by individuals over the age of 1 year as a protein source when essential amino acids are required rather than whole protein, peptides, or a complete mixture of amino acids in the dietary management of:

  • Conditions in which a nutritionally complete formula is not suitable
  • Conditions in which a modular dietary approach is needed.

Good to Know

  • Made in a dairy protein-free facility
  • No artificial colors, flavors, sweeteners

Essential Amino Acid Mix is a specially formulated medical food and should only be used under medical supervision.

 
Features & Characteristics
Calories per 200 gram can (kcal) 632
Calories per gram (kcal) 3.16
Approximate Displacement, mL/g 0.75
Osmolality (5% w/v), mOsm/kg H2O 360
Milliosmoles contributed by 1 gram of Essential Amino Acid Mix added to a solution 7.2
Protein Equivalent per 5 g powder, g 4
Protein Equivalent per 100 g powder, g 79
Ordering & Reimbursement
Product Code Reimbursement Code HCPCS Code Product Packaging
53342 49735-0114-90 B4155 6 x 200 g (7 oz)

WIC*: Contact your state WIC office to determine availability

Reimbursement codes have been submitted by Nutricia North America to US data warehouses based on the format established by the data warehouses. These codes are not NDC numbers.
WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants and Children. WIC eligible means that a product has been approved at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area.
Nutrition
Nutrients Per 100 g
Calories 316
Protein Equivalent, g 79
Fat, g None
Carbohydrate, g None

 

Amino Acids, g Per 100 g
L-Cystine 3.78
L-Histidine 3.78
L-Isoleucine 10.4
L-Leucine 16.17
L-Lysine 13.25
L-Methionine 3.78
L-Phenylalanine 5.67
L-Threonine 11.35
L-Tryptophan 2.36
L-Tyrosine 9.46
L-Valine 14.56
Ingredients

L-Lysine Acetate, L-Leucine, L-Valine, L-Threonine, L-Isoleucine, L-Tyrosine, L-Phenylalanine, L-Histidine, L-Cystine, L-Methionine, L-Tryptophan.

Preparation & Storage

Directions for Preparation and Use:

Dosage should be determined by a healthcare professional and is dependent on the age, body weight, and medical condition of the patient. Not for parenteral use. Not suitable for use as a sole source of nutrition - must be given in conjunction with other sources of nutrition to supply the fluid and general nutrition requirements of the patient in quantities as prescribed by a clinician or dietitian.

Essential Amino Acid Mix may be taken as a drink or paste, and is best served as a chilled drink, mixed with water, fruit juices or other formulas.

  • The recommended mixing concentration is 5% w/v (e.g. 5 g of powder to 100 mL of water).
  • Essential Amino Acid Mix should be weighed on a scale that reads in grams.
  • Make a paste of the required amount of powder with a small volume of chilled water or other liquid.
  • Fill up to the desired final volume.
  • The daily intake of Essential Amino Acid Mix should be divided into equal portions and distributed throughout the day.

For best results, consume immediately. Essential Amino Acid Mix may also be added to soft foods, such as applesauce.

Storage:

Store in a cool, dry place. Once opened, use within one month. Always replace the container lid after use. Once reconstituted, the prepared feeding should be stored in a refrigerator and must not be kept longer than 24 hours from the time of preparation. Stir or shake immediately before serving.

Resources & Downloads

Healthcare professionals can access helpful information and resources online for Essential Amino Acid Mix through the Nutricia Learning Center. It’s easy and free to register for access to the following:

For patient safety, Nutricia directs parents and caregivers requesting specialized information, such as household measures, to their healthcare teams.

Complete Amino Acid Mix
Complete Amino Acid Mix

Complete Amino Acid Mix is an unflavored, powdered mix of essential and non-essential amino acids. Complete Amino Acid Mix is specially formulated for use by individuals over the age of 1 year as a protein source when amino acids are required rather than whole protein or peptides in the dietary management of:

  • Conditions in which a nutritionally complete feed is not suitable or a modular diet approach is required
  • Conditions where an oligoallergenic diet is indicated (e.g. eosinphilic esophagitis or individuals with intolerance to milk protein or other whole protein)
  • Intractable malabsorption
  • Feeding difficulties in post-operative conditions
  • Chronic intestinal diseases (e.g. Crohn’s disease)
  • Short bowel syndrome following intestinal resection

Good to Know

  • Made in a dairy protein-free facility
  • No artificial colors, flavors, sweeteners

Complete Amino Acid Mix is a specially formulated medical food and should only be used under medical supervision.

 
Features & Characteristics
Calories per 200 gram can (kcal) 656
Calories per gram (kcal) 3.28
Approximate Displacement, mL/g 0.75
Osmolality (5% w/v), mOsm/kg H2O 360
Milliosmoles contributed by 1 gram of Complete Amino Acid Mix added to a solution 7.2
Protein Equivalent per 5 g powder, g 4
Protein Equivalent per 100 g powder, g 82
Ordering & Reimbursement
Product Code Reimbursement Code HCPCS Code Product Packaging
53341 49735-013341 B4155 6 x 200 g (7 oz)

WIC*: Contact your state WIC office to determine availability

Reimbursement codes have been submitted by Nutricia North America to US data warehouses based on the format established by the data warehouses. These codes are not NDC numbers.
WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants and Children. WIC eligible means that a product has been approved at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area
Nutrition
Nutrients Per 100 g
Calories 328
Protein Equivalent, g 82 g
Fat, g None
Carbohydrate, g None

 

Amino Acids
L-Alanine 3.5 g
L-Arginine 7.66 g
L-Aspartic Acid 6.39 g
L-Cystine 2.4 g
L-Glutamic Acid 8.17 g
Glycine 6.0 g
L-Histidine 4.38 g
L-Isoleucine 5.95 g
L-Leucine 10.22 g
L-Lysine 7.55 g
L-Methionine 1.65 g
L-Phenylalanine 4.5 g
L-Proline 7.0 g
L-Serine 4.29 g
L-Threonine 5.0 g
L-Tryptophan 2.0 g
L-Tyrosine 4.3 g
L-Valine 6.5 g
L-Glutamine 0.7 g

 

Ingredients

L-Lysine L-Glutamate, L-Leucine, L-Arginine, L-Proline, L-Valine, L-Aspartic Acid, Glycine, L-Isoleucine, L-Threonine, L-Phenylalanine, L-Histidine, L-Serine, L-Tyrosine, L-Alanine, L-Cystine, L-Tryptophan, L-Methionine, L-Glutamine, L-Glutamic Acid.

Preparation & Storage

Directions for Preparation and Use:

Dosage should be determined by a healthcare professional and is dependent on the age, body weight, and medical condition of the patient. Not for parenteral use. Not suitable for use as a sole source of nutrition - must be given in conjunction with other sources of nutrition to supply the fluid and general nutrition requirements of the patient in quantities as prescribed by a clinician or dietitian.

Complete Amino Acid Mix may be taken as a drink or paste, and is best served as a chilled drink, mixed with water, fruit juices or other formulas.

  • The recommended mixing concentration is 5% w/v (e.g. 5 g of powder to 100 mL of water).
  • Complete Amino Acid Mix should be weighed on a scale that reads in grams.
  • Make a paste of the required amount of powder with a small volume of chilled water or other liquid.
  • Fill up to the desired final volume.
  • The daily intake of Complete Amino Acid Mix should be divided into equal portions and distributed throughout the day.

For best results, consume immediately. Complete Amino Acid Mix may also be added to soft foods, such as applesauce.

Storage:

Store in a cool, dry place. Once opened, use within one month. Always replace the container lid after use. Once reconstituted, the prepared feeding should be stored in a refrigerator and must not be kept longer than 24 hours from the time of preparation. Stir or shake immediately before serving.

Resources & Downloads

Healthcare professionals can access helpful information and resources online for Complete Amino Acid Mix through the Nutricia Learning Center. It’s easy and free to register for access to the following:

For patient safety, Nutricia directs parents and caregivers requesting specialized information, such as household measures, to their healthcare teams.

Pepticate<sup><sup>™</sup></sup> Infant
Pepticate™ Infant

Pepticate is a specially formulated hypoallergenic, whey-based, extensively hydrolyzed infant formula (eHF) for the dietary management of infants with cow milk allergy and colic related to cow milk allergy.

Pepticate is:

  • Hypoallergenic1,2 – effectively relieves food allergy symptoms
  • Clinically shown to support growth1,3
  • The #1 best-tasting hypoallergenic eHF rated by parents*

Pepticate is indicated for infants 0-12 months of age with cow milk allergy and colic related to cow milk allergy and should be used under medical supervision.

Reassuring to know

  • Contains lactose, which is found naturally in human milk,4 helping make the formula more palatable5
  • Added prebiotic fiber blend of scGOS/lcFOS in a 9:1 ratio to support infant digestive health6,7
  • Added nucleotides, which are naturally present in human milk,8 shown to help support the immune system9
  • Added DHA & ARA to promote brain and eye development10
  • No added soy oil
  • No gluten added
  • No artificial colors, flavors, or sweeteners

*Based on an April 2024 nationwide taste test, among parents, of powdered eHFs.

scGOS = short-chain galacto-oligosaccharides; lcFOS = long-chain fructooligosaccharides

 
Features & Characteristics

Main Features:

  • DHA at 0.38% fatty acids
  • DHA and ARA at 1:1 ratio
  • Energy distribution:
    • Protein 9.6%
    • Carbohydrate 47.9%
    • Fat (MCT 15% / LCT 85%) 47.9%
  • Potential renal solute load (at 20 kcal/fl oz):158 mOsm/L
  • Osmolality (at 20 kcal/fl oz): 300 mOsm/kg H2O
  • Free water (at 20 kcal/fl oz): ~90.0%
  • Displacement: 0.70 mL/g

Additional Details

Calories per 375 gram can (kcal) 1774
Calories per gram (kcal) 4.73
Grams/scoop (level, unpacked) 4.8
Calories/scoop (kcal) 22.7
Water displaced/gram (mL) 0.70
Water displaced/scoop (mL) 3.36
Protein Equivalent/scoop (g) 0.55
Protein Equivalent, g/100 mL† 2.4
Volume of prepared formula per can†

~86 fl oz

~2580 mL
Scoops per can ~78

†At standard dilution, 20 kcal/fl oz

Ordering and reimbursement

Pepticate™ is available to healthcare professionals to sample. Contact your Nutricia sales representative to request samples to be sent to your practice.

  Product Code NDC-Format Code*/Reimbursement Code HCPCS Code Product Packaging
Can 197602 49735-0101-01 B4161 1 x 375 g (13.2 oz)
Case 199359 49735-0101-02 B4161 4 x 375 g (3 lbs 4.8 oz)

WIC: Pepticate is WIC eligible.†

*NDC-format codes are product codes adjusted according to standard industry practice to meet the format requirements of pharmacy and health insurance systems. Nutricia North America does not represent these codes to be National Drug Codes (NDCs).

†WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants, and Children. WIC eligible means that a product has been authorized at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area – fns.usda.gov/wic

If patients are in need of assistance with insurance coverage questions please contact Nutricia Navigator at 800-365-7354, Monday-Friday, 9:00 am - 6:00 pm ET.

Nutrition
NUTRIENTS Per 100 Calories (5 fl oz when prepared as directed)
Calories 100
Protein Equivalent, g 2.4
Fat, g 4.7
Carbohydrate, g 12.5
Soluble Fiber, g 0.72
Water, g 132
Linoleic Acid, mg 794

 

VITAMINS
Vitamin A, IU (mcg RE) 289 (86.7)
Vitamin D, IU (mcg) 68.0 (1.7)
Vitamin E, IU (mg α-TE) 2.7 (1.8)
Vitamin K, mcg 7.6
Thiamine, mcg 101
Riboflavin, mcg 212
Vitamin B6, mcg 52.3
Vitamin B12, mcg 0.18
Niacin, mcg 1059
Folic acid, mcg 15.5
Pantothenic acid, mcg 815
Biotin, mcg 2.5
Vitamin C, mg 10.3
Choline, mg 23.9
Inositol, mg 8.2

 

Minerals
Calcium, mg 103
Phosphorus, mg 65.0
Magnesium, mg 10.1
Iron, mg 1.5
Zinc, mg 0.90
Manganese, mcg 10.0
Copper, mcg 66.2
Iodine, mcg 20.3
Selenium, mcg 3.7
Sodium, mg 34.7
Potassium, mg 104
Chloride, mg 74.9
Ingredients

Maltodextrin, Whey Protein Hydrolysate (Milk),‡ Refined Vegetable Oils (Palm, Coconut, Canola, and Sunflower Oils), Galacto-oligosaccharides (Milk), and less than 2% of each of the following: Calcium Phosphate, Citric Acid Esters of Mono- and Diglycerides, Fructooligosaccharides, Tuna Fish Oil,§ Potassium Chloride, Magnesium Hydrogen Phosphate, M. Alpina Oil,∥Sodium Chloride, Choline Chloride, L-Tyrosine, L-Ascorbic Acid, Inositol, Taurine, Sodium L-Ascorbate, Ferrous Sulfate, Zinc Sulfate, L-Carnitine, Sodium Citrate, DL-Alpha Tocopheryl Acetate, Calcium D-Pantothenate, Niacinamide, Copper Sulfate, DL-Alpha Tocopherol, Vitamin A Palmitate, Riboflavin, Thiamine Hydrochloride, Pyridoxine Hydrochloride, Potassium Iodide, Folic Acid, Manganese Sulfate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D3, Cyanocobalamin, Ascorbyl Palmitate, Calcium Hydroxide, Potassium Hydroxide, Nucleotides (Disodium Uridine 5’-Monophosphate, Cytidine 5’-Monophosphate, Disodium Inosine 5’-Monophosphate, Adenosine 5’-Monophosphate, Disodium Guanosine 5’- Monophosphate).

‡Modified to be better tolerated in infants with cow milk allergy

§A source of docosahexaenoic acid (DHA)

∥A source of arachidonic acid (ARA)

Preparation

Directions for Preparation and Use:

Suitable as a sole source of nutrition for infants under 1 year of age. Suggested intake should be determined by a healthcare professional and will vary depending on the age, body weight, and medical condition of the infant. Proper hygiene is important when preparing infant formula.

Ask your baby’s healthcare team if you need to use cooled, boiled water for mixing and if you need to boil (sterilize) bottles, nipples, and rings before use.

 

Pepticate infant Preparation

  1. 1. Wash hands thoroughly and clean the preparation area.
  2. 2. To make the standard dilution (20 calories/fl oz), add 1 unpacked, level scoop (4.8 g) of powder to each 1 fl oz of water.
  3. 3. Cap bottle; shake well until powder dissolves. Freshly prepared formula is best. Once feeding begins, use within 1 hour or discard. Only if necessary, refrigerate freshly prepared formula between 35-40°F (2-4°C) and use within 24 hours. Do not boil or do not use a microwave oven to warm formula; serious burns may result.

Pepticate Infant Prep Chart

One can of Pepticate makes approximately 86 fl oz when prepared at the standard dilution (20 kcal/fl oz).

Storage: Store unopened or opened can in a cool, dry place. Once opened, replace can lid and use within 1 month. Do not store at extreme temperatures.

Precautions: Powdered formulas are not sterile. Not for use in premature infants or infants who are immunocompromised unless directed by a healthcare professional. For oral and tube feeding only; not for parenteral use. Not suitable for infants with galactosemia due to the presence of lactose.

Research & References

Review our evidence booklet to learn more about the evidence supporting Pepticate.

  1. 1. Verwimp JJ, Bindels JG, Barents M, Heymans HSSFN. Symptomatology and growth in infants with cow's milk protein intolerance using two different whey-protein hydrolysate based formulas in a Primary Health Care setting. European Journal of Clinical Nutrition. 1995;49:S39-48.
  2. 2. Giampietro PG, Kjellman NI, Oldaeus G, et al. Hypoallergenicity of an extensively hydrolyzed whey formula. Pediatr Allergy Immunol. 2001;12:83-6.
  3. 3. Abrahamse-Berkeveld M, Alles M, Franke-Beckmann E, et al. Infant formula containing galacto-and fructo-oligosaccharides and Bifidobacterium breve M-16V supports adequate growth and tolerance in healthy infants in a randomised, controlled, double-blind, prospective, multicentre study. J Nutr Sci. 2016;5:e42.
  4. 4. Kunz C, Rudloff S, Baier W, et al. Oligosaccharides in human milk: structural, functional, and metabolic aspects. Annu Rev Nutr. 2000;20:699-722.
  5. 5. Maslin K, Fox AT, Chambault M, Meyer R. Palatability of hypoallergenic formulas for cow's milk allergy and healthcare professional recommendation. Pediatr Allergy Immunol. 2018;29:857-62.
  6. 6. Moro G, Minoli I, Mosca M, et al. Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. J Pediatr Gastroenterol Nutr. 2002;34:291-5.
  7. 7. Knol J, van der Linde EGM, Wells JCK, Bockler HM. An infant formula containing prebiotics changes the intestinal microbiota of term infants. J Pediatr Gastroenterol Nutr. 2003;36:566.
  8. 8. Field CJ. The immunological components of human milk and their effect on immune development in infants. J Nutr. 2005;135:1-4.
  9. 9. Gutiérrez-Castrellón P, Mora-Magana I, Díaz-García L, et al. Immune response to nucleotide-supplemented infant formulae: systematic review and meta-analysis. Br J Nutr. 2007;98:S64-7.
  10. 10. Birch EE, Carlson SE, Hoffman DR, et al. The DIAMOND (DHA Intake And Measurement Of Neural Development) Study: a double-masked, randomized controlled clinical trial of the maturation of infant visual acuity as a function of the dietary level of docosahexaenoic acid. Am J Clin Nutr. 2010;91:848-59.
Resources and downloads
Neocate<sup>®</sup> Syneo<sup>®</sup> Junior
Neocate® Syneo® Junior

Neocate Syneo Junior is the only amino acid-based formula with the Syneo blend of prebiotic fibers and probiotics, specifically designed for children 1 to 10 years of age with food allergies.

Neocate Syneo Junior is:

  • Hypoallergenic – relieves food allergy symptoms
    • Based on 100% non-allergenic free amino acids
  • Nutritionally complete

Neocate Syneo Junior is a medical food indicated for the dietary management of cow milk allergy, multiple food allergies, and related gastrointestinal (GI) and allergic conditions, including eosinophilic GI disorders (EGIDs), food protein-induced enterocolitis syndrome (FPIES), and gastroesophageal reflux related to food allergies. Neocate Syneo Junior should only be used under medical supervision.

Reassuring to know

  • Contains prebiotic fibers (scFOS/lcFOS) and probiotics (Bifidobacterium breve M-16V) to support digestive
    health1-5
  • Dairy free
  • Made in a milk protein-free facility
  • No added soy oil
  • No gluten added
  • No artificial colors, flavors, or sweeteners
  • Kosher Pareve
  • Halal

scFOS = short-chain fructooligosaccharides; lcFOS = long-chain fructooligosaccharides

 
Features & Characteristics
  • Energy distribution:
    • Protein                                         12.6%
    • Carbohydrate                            44.2%
    • Fat (MCT 34% / LCT 66%) 43.2%

 

Calories per 400 gram can (kcal) 1876
Calories per gram (kcal) 4.69
Grams/scoop (level, unpacked) 7.6
Calories/scoop (kcal) 35.6
Water displaced/gram (mL) 0.74
Water displaced/scoop (mL) 5.6
Protein Equivalent/scoop (g) 1.1
Protein Equivalent, g/100 mL* 3.2
Displacement, mL/g 0.74
Volume of prepared formula per can* ~62 fl oz
~1860 mL
Scoops per can ~52
Osmolality, mOsm/kg H2O* 600
Free water* ~84.6%

*At standard dilution, 30 kcal/fl oz

Meets or exceeds 100% DRIs6,7 for protein + 25 key vitamins & minerals:

Ages 1-3 years

930 mL

Ages 4-8 years

1370 mL

Ages 9-10 years

1565 mL
Ordering & Reimbursement

Neocate Syneo Junior is available to healthcare professionals to sample. Contact your Nutricia sales representative to request samples to be sent free of charge to your practice.

 

Product Code

NDC-Format Code*/Reimbursement Code

HCPCS Code

Product Packaging

Neocate Syneo Junior

196062

49735-0100-99

B4161

4 x 400 g (14.1 oz)

WIC: Neocate products are WIC eligible in all states. † 

*Nutricia North America does not represent these codes to be National Drug Codes (NDCs). NDC-format codes are product codes adjusted according to standard industry practice to meet the format requirements of pharmacy and health insurance systems.

†WIC is a registered service mark of the U.S. Department of Agriculture for USDA's Special Supplemental Nutrition Program for Women, Infants, and Children. WIC eligible means that a product has been authorized at the Federal level and, therefore, may be included on a State agency's authorized food list if the State agency so chooses. Each WIC State agency determines its own allowed formula list. Contact your State WIC office to determine the availability of a specific WIC eligible Nutricia product in your area – fns.usda.gov/wic

Nutrition
NUTRIENTS Per 100 Calories (100 mL prepared as directed)
Calories 100
Protein Equivalent, g 3.2
Fat, g 4.8
Carbohydrate 11.3
Soluble Fiber, g 0.60

 

VITAMINS
Vitamin A, IU (mcg RE) 204 (61.2)
Vitamin D, IU (mcg) 81.0 (2.0)
Vitamin E, IU (mg α-TE) 2.1 (1.4)
Vitamin K, mcg 4.2
Thiamine, mg 0.10
Riboflavin, mg 0.20
Vitamin B6, mg 0.10
Vitamin B12, mcg 0.41
Niacin, mg 0.92
Folic acid, mcg 18.3
Pantothenic acid, mg 0.41
Biotin, mcg 3.1
Vitamin C, mg 9.5
Choline, mg 30.5
Inositol, mg 22.3

 

MINERALS
Calcium, mg 125
Phosphorus, mg 81.3
Magnesium, mg 16.3
Iron, mg 1.6
Zinc, mg 1.0
Manganese, mg 0.07
Copper, mcg 100
Iodine, mcg 15.1
Molybdenum, mcg 4.8
Chromium, mcg 3.9
Selenium, mcg 4.1
Sodium, mg 50.4
Potassium, mg 139
Chloride, mg 76.6
Ingredients

Corn Syrup Solids, Refined Vegetable Oils (Medium Chain Triglycerides [Coconut and/or Palm and/or Palm Kernel Oils], High Oleic Sunflower, Canola, and Sunflower Oils), Fructooligosaccharides (Oligofructose, Inulin), L-Serine, and less than 2% of the following: L-Glutamine, Glycine, L-Alanine, L-Leucine, L-Lysine Acetate, L-Threonine, L-Tyrosine, Dipotassium Phosphate, L-Valine, Citric Acid Esters of Mono- and Diglycerides, Tricalcium Phosphate, L-Isoleucine, Tripotassium Citrate, Calcium Carbonate, L-Proline, L-Cystine, L-Phenylalanine, L-Histidine, Magnesium Hydrogen Phosphate, Sodium Chloride, L-Methionine, Choline Bitartrate, L-Arginine, Sodium Citrate, L-Tryptophan, Magnesium Chloride, Calcium Chloride, M-Inositol, L-Ascorbic Acid, Sunflower Lecithin, Taurine, Ferrous Sulfate, L-Carnitine, Bifidobacterium breve M-16V, Zinc Sulfate, Ascorbyl Palmitate, Niacinamide, Calcium D-Pantothenate, DL-alpha Tocopheryl Acetate, Copper Sulfate, Riboflavin, Manganese Sulfate, Thiamine Hydrochloride, Pyridoxine Hydrochloride, Vitamin A Acetate, Folic Acid, Potassium Iodide, Chromium Chloride, DL-alpha Tocopherol, Sodium Molybdate, Sodium Selenite, Phylloquinone, D-Biotin, Vitamin D3, Cyanocobalamin.

Preparation & Storage

Suitable for use as a supplement or sole source of nutrition for children 1 – 10 years of age. Suggested intake to be determined by a healthcare professional and is dependent on age, body weight, and medical condition of the child.

  1. Wash hands thoroughly and clean the preparation area.
  2. To make the standard dilution (30 calories/fl oz), add 1 unpacked, level scoop (7.6 g) of powder to each 1 fl oz of water.
  3. Stir, or cover and shake, until the powder has dissolved. Feed immediately or refrigerate immediately and use within 24 hours. Once feeding begins, use within 1 hour or discard. If taken orally, Neocate Syneo Junior is best served chilled. Mixing with water warmer than 104°F (40°C) may lessen the benefits of the probiotic cultures. Do not boil or do not use a microwave to warm formula; serious burns may result.

Amount of water

Amount of Neocate to add

Approximate final volume

4 fl oz

4 scoops or 30.4 g

4.7 fl oz

7 fl oz

7 scoops or 53.2 g

8.3 fl oz

21 fl oz

21 scoops or 160 g

24.9 fl oz

One can of Neocate Syneo Junior makes approximately 62 fl oz when prepared at the standard dilution (30 kcal/fl oz)

Storage: Store unopened or opened can in a cool, dry place. Once opened, replace can lid and use within 2 weeks. Do not store at extreme temperatures.

Precautions: Not for use in those who are immunocompromised. Not recommended for use in those with a central venous catheter or post-pyloric feeding tube unless directed by a healthcare professional.

Research & References

Over 210 publications and counting support the use of Neocate in a wide variety of conditions and ages. Of those, there are more than 70 publications on the clinical use of Neocate formulas for the dietary management of cow milk allergy, multiple food allergies, and related gastrointestinal (GI) and allergic conditions, including eosinophilic GI disorders, short bowel syndrome, and gastroesophageal reflux related to food allergies. There are also many case studies that discuss the successful use of Neocate in these and other conditions, and preclinical studies on Neocate.

Healthcare professionals can review the science behind Neocate through the Nutricia Learning Center. It’s easy and free to register for access to the following:

REFERENCES:

  1. Elia M, Engfer MB, Green CJ, et al. Systematic review and meta-analysis: the clinical and physiological effects of fibre-containing enteral formulae. Aliment Pharmacol Ther. 2008;27:120-45.
  2. Cummings JH. Prebiotics and the gut barrier to infection. J Pediatr Gastroenterol Nutr. 2004;39:S555.
  3. Brownawell AM, Caers W, Gibson GR, et al. Prebiotics and the health benefits of fiber: current regulatory status, future research, and goals. J Nutr. 2012;142:962-74.
  4. Bosscher D, Van Loo J, Franck A. Inulin and oligofructose as prebiotics in the prevention of intestinal infections and diseases. Nutr Res Rev. 2006;19:216-26.
  5. Chatchatee P, Nowak-Wegrzyn A, Lange L, et al. Tolerance development in cow's milk-allergic infants receiving amino acid-based formula: A randomized controlled trial. J Allergy Clin Immunol. 2022;149:650-8.e5.
  6. Food and Nutrition Board, Institute of Medicine; Otten JJ, Hellwig JP, Meyers LD, Eds. Dietary Reference Intakes: The Essential Guide to Nutrient Requirements. Institute of Medicine (IOM) of the National Academies, Washington, DC: National Academies Press; 2006.
  7. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium; Ross AC, Taylor CL, Yaktine AL, et al, Eds. Dietary reference intakes for calcium and vitamin D. Institute of Medicine (IOM) of the National Academies, Washington, DC: National Academies Press; 2011.
Resources & Downloads

• Free CE-eligible webinars
• Flow Charts for Nutrition Management

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