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Food protein-induced enterocolitis syndrome typically affects infants and young children. It is also called FPIES – pronounced like the letter “F” followed by the word “pies.” FPIES is a rare type of food allergy that affects the digestive tract. Symptoms show up a few hours after eating. The hallmark symptom is severe vomiting. There can also be diarrhea, lethargy, dehydration, low blood pressure, and low body temperature. Milk, soy, rice, and oats are...

Food protein-induced enterocolitis syndrome typically affects infants and young children. It is also called FPIES – pronounced like the letter “F” followed by the word “pies.” FPIES is a rare type of food allergy that affects the digestive tract. Symptoms show up a few hours after eating. The hallmark symptom is severe vomiting. There can also be diarrhea, lethargy, dehydration, low blood pressure, and low body temperature. Milk, soy, rice, and oats are...

...often shows up in babies after their first formulas or solid foods are introduced. A baby with FPIES may successfully take breastmilk, then develop FPIES symptoms when a cow milk or soy-based infant formula is started. Very rarely, FPIES has occurred in exclusively breastfed babies. FPIES is a non-IgE mediated immune reaction in the gastrointestinal (GI) tract. The immunoglobulin E (IgE) antibodies involved in other food allergy reactions are not involved in an FPIES reaction....

...FPIES can be hard to diagnose. Blood allergy tests can help reveal IgE-mediated food allergies, but FPIES is a non-IgE-mediated disorder. So far, there is no valid laboratory or skin test for FPIES. Furthermore, FPIES reactions are often mistaken for something else, like a stomach bug. The lag time between feeding and the onset of symptoms can cloud connection between cause and effect. Often, FPIES is only suspected after multiple allergic reactions....