Neocate and Multiple allergy
Infants and children with allergy to cow milk can exhibit sensitivity to other food proteins, a condition termed Multiple Food Protein Intolerance (MFPI): in more than 50% of children with food allergy, adverse reactions to more than one food are seen. Children with multiple food protein intolerance are allergic to a wide range of foods (milk, soy, egg, wheat, peanut, fish, meats and rice) and to extensively hydrolyzed formula (eHF).
Infants with cow milk allergy, intolerance to extensively hydrolyzed formula (eHF) and soy were safely and effectively treated in the long term with Neocate.
Allergies in infancy can resolve over time. During this time, Neocate can be used to provide an adequate source of nutrition for normal and catch up growth.*
*The following two studies demonstrate the successful use of Neocate in this condition with resolution of clinical symptoms and promotion of normal growth:
- Hill et al (1995)
Eighteen infants with multiple food protein intolerance, including intolerance to soy, casein and whey hydrolysates, with chronic ill health, were given Neocate for a median period of 14 weeks (8-28 weeks). All responded with resolution of symptoms within 14 days of commencing the product. Four patients with growth failure showed a gradual increase in weight over the 28 days. Then, 7 day, Double Blind Placebo Controlled challenges (DBPC) with the formula previously best tolerated were performed in each infant.
- Boissieu D, Dupont C. (2000)
Time course of allergy to extensively cows milk proteins in infants.
Objective of this study is to assess the duration of allergy to extensively hydrolysed cow’s milk formula (EHF) in infants allergic both to cow’s milk and EHF, and to assess the effectiveness of amino acid-based formula (AAF) in EHF-intolerant patients.
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