HOW COMMON IS COW MILK ALLERGY (CMA)?
Cow milk allergy (CMA)
is the most common food allergy in infants.1
Worldwide, around 2-5% of babies suffer from the allergy each year. In the U.S., that equates to roughly 75,000 children.1-4
Parents say that seeing their child struggle with the symptoms of CMA is stressful – fortunately, you can effectively manage symptoms with a specialized hypoallergenic formula for patients with CMA.
Not all CMA formulas are created equal
EXTENSIVELY HYDROLYZED FORMULA (eHF)
OFTEN RECOMMENDED, BUT STILL CARRIES RISK
- eHF contains peptides derived from cow milk
- Up to 40% of infants with severe CMA are intolerant to eHF5
- Up to 10% of infants with uncomplicated CMA are intolerant to eHF5,6
Contains fragments of cow milk protein
AMINO ACID-BASED FORMULA (AAF)
A SAFE, RELIABLE OPTION
- AAF is completely cow-milk free
- 100% non-allergenic amino acids
- Zero allergic reactions in published hypoallergenicity trials*
*In clinical trials, allergic reactions to amino acid-based formulas have not been reported in patients with food allergies during open and blinded formula challenges7-11
Try the most hypoallergenic type of formula on the market.
See how you can give your patients with CMA safe, effective symptom management with an AAF from Neocate®.
Four signs you should use an amino acid-based formula (like Neocate) first – to help manage your patients with cow milk allergy
especially with gastrointestinal/skin
symptoms, or with multiple food eliminations12-14
When food allergies like CMA aren’t under control, children can experience poor growth. And when poor growth presents in conjunction with gastrointestinal (GI) tract and/or skin symptoms, the evidence supports using an AAF over an eHF.12-14 That’s because gastroesophageal reflux related to severe CMA may be associated with poor weight gain,12,15 while skin symptoms can signal inflammation that can increase nutrient needs.14
In addition, infants who must avoid three or more foods due to allergies have been found to have worse growth parameters and nutritional intake14,16 – so if you’ve recommended multiple food eliminations for your patient, you should also consider recommending Neocate.
Allergic conditions that affect the GI system – like cow milk allergy – can be severe, and might indicate the need for a hypoallergenic formula like Neocate.12,14,17,18 While “severe” isn’t clearly defined, blood in the stool that doesn’t respond to management is one sign of a severe GI allergy.13,19
Anaphylactic reactions to cow milk occur in between 0.8%-9.0% of CMA cases.14,17 Because anaphylactic reactions to food allergens can be severe and life-threatening, consensus guidelines from an international panel recommend a hypoallergenic AAF like Neocate in these cases.14,17
SYMPTOMS NOT RESOLVED
Because guidelines generally recommend trying an eHF first, you may not have gone straight to an amino acid-based formula. However, if food allergy symptoms don’t completely resolve within 2-4 weeks on an eHF, international guidelines recommend using an AAF like Neocate.6,12
If you see any of these signs in your patients with cow milk allergy, try Neocate.
According to guidelines and research, any of these four signs indicates the need for an amino acid-based formula. See how Neocate can make a difference for your patients.
provide safe and effective symptom management with Neocate
Neocate offers a full range of AAF options tailored to help manage food allergy symptoms – in more flavors and formats than any other amino acid-based formula.
We’re endlessly devoted to developing life-changing products for your patients, and we always strive to provide the most robust evidence regarding efficacy, tolerance, and growth – so you can feel confident choosing Neocate for safe and effective management of CMA.
MORE EVIDENCE, MORE CONFIDENCE
200+ publications support Neocate – more than any other brand of AAF
|Neocate® Syneo® Infant||Neocate® Infant||Neocate® Nutra||Neocate® Junior||Neocate® Splash|
Neocate® Syneo® Infant
- 0-12 months
- First and only hypoallergenic formula with prebiotics and probiotics, to help balance the gut microbiota20 to support the developing immune system
- Added nucleotides & DHA/ARA
- 0-12 months
- Added nucleotides
- Added DHA/ARA
- 6+ months
- Cereal-style option to promote oral development21
- Forms a smooth, pudding style consistency when mixed with water – ideal for adding texture and variety to meals
- 1+ years
- First hypoallergenic formula with prebiotic fiber, to help support digestive health22-25
- Available in 6 flavors
- 1+ years
- First and only ready-to-feed hypoallergenic formula specifically designed to address the growing nutritional and lifestyle needs of toddlers, older children and teens
- Ideal for oral and tube feeding
- Available in 4 flavors
See for yourself how effectively Neocate can resolve CMA symptoms – request a sample today!
Sign up to receive a free sample of Neocate, so you can confidently manage your CMA patients’ symptoms.
1. Gupta, et al. Pediatrics. 2011;128:e9-e17. 2. Fiocchi, et al. Pediatr Allergy Immunol. 2010;21 Suppl 21:1-125. 3. Warren, et al. Annals of Allergy, Asthma & Immunology. 2018;121:S13. 4. Martin, et al. Births: Final data for 2019. https://stacks.cdc.gov/view/cdc/100472. Accessed 4/23/2021. 5. Hill, et al. Clin Exp Allergy. 2007;37:808-22. 6. Koletzko, et al. J Pediatr Gastroenterol Nutr. 2012;55:221-9. 7. Sampson, et al. Pediatrics. 1992;90:463-5. 8. Isolauri, et al. AAAAI 60th Annual Meeting; 2004. 9. Nutricia North America – Data on file. 2008. 10. Harvey, et al. Pediatr Res. 2014;75:343-51. 11. Payot, et al. J Pediatr Gastroenterol Nutr. 2018;66:135-40. 12. Venter, et al. Clin Transl Allergy. 2013;3:23. 13. Ludman, et al. BMJ. 2013;347:f5424. 14. Meyer, et al. J Allergy Clin Immunol Pract. 2018;6:383-99. 15. Vandenplas, et al. Arch Dis Child. 2007;92:902-8. 16. Meyer, et al. J Hum Nutr Diet. 2014;27:227-35. 17. Fiocchi, et al. Pediatr Allergy Immunol. 2010;21 Suppl 21:1-125. 18. Motala, et al. http://www.worldallergy.org/professional/allergic_diseases_center/cows_milk_allergy_in_children/ [March 6, 2019]. 19. Groetch, et al. J Allergy Clin Immunol Pract. 2013;1:323-31. 20. Candy, et al. Pediatr Res. 2018;83:677-86. 21. Haas. Nutr Clin Pract. 2011;26:E19(N36). 22. Elia, et al. Aliment Pharmacol Ther. 2008;27:120-45. 23. Cummings. J Pediatr Gastroenterol Nutr. 2004;39:S555. 24. Bosscher, et al. Nutr Res Rev. 2006;19:216-26. 25. Brownawell, et al. J Nutr. 2012;142:962-74.